Taste disorders are partly genetically determined: Role of the TAS2R38 gene, a pilot study.
Phenylthiocarbamide responsiveness
TAS2R38 bitter receptor
taste disorders
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
28
09
2018
revised:
08
11
2018
accepted:
04
12
2018
pubmed:
25
1
2019
medline:
24
10
2019
entrez:
25
1
2019
Statut:
ppublish
Résumé
Taste sensitivity varies greatly among individuals influencing eating behavior and health, consequently the disorders of this sense can affect the quality of life. The ability to perceive the bitter of thiourea compounds, such as phenylthiocarbamide (PTC), has been largely reported as a marker of the general taste sensitivity, food preferences, and health. PTC sensitivity is mediated by the TAS2R38 receptor and its genetic common variants. We study the role of the TAS2R38 receptor in taste disorders with the aim of understanding if these can be genetically determined. Prospective cohort study. Differences in the PTC responsiveness between the patients cohort and healthy controls were assessed. All subjects received standardized tests for smell and taste function and were genotyped for the TAS2R38 gene. PAV/PAV homozygous patients gave high PTC ratings, whereas PAV/AVI genotypes reported lower values, which are similar to those determined in AVI/AVI or rare genotypes. In addition, the patients cohort did not meet the Hardy-Weinberg equilibrium at the TAS2R38 locus, showing a very low frequency of subjects carrying the PAV/AVI diplotype. Independently, in healthy controls who were in equilibrium at the locus, PAV/PAV homozygous and heterozygous rated PTC bitterness higher compared to AVI/AVI or rare genotypes. Our findings, by showing that an only taster haplotype (PAV) is not sufficient to evoke high responses of TAS2R38 receptor in patients with taste disorders, suggest that the genetic constitution may represent a risk factor for the development of taste disorders. 2c Laryngoscope, 129:E307-E312, 2019.
Substances chimiques
Receptors, G-Protein-Coupled
0
taste receptors, type 2
0
Phenylthiourea
6F82C6Q54C
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E307-E312Informations de copyright
© 2019 The American Laryngological, Rhinological and Otological Society, Inc.
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