Unraveling Specific Brain Microstructural Damage in Moyamoya Disease Using Diffusion Magnetic Resonance Imaging and Positron Emission Tomography.
Adolescent
Adult
Axons
/ pathology
Brain
/ blood supply
Brain Ischemia
/ diagnostic imaging
Case-Control Studies
Cerebral Angiography
/ methods
Cerebrovascular Circulation
Cognition
Diffusion Magnetic Resonance Imaging
Female
Hemodynamics
Humans
Magnetic Resonance Angiography
Male
Microcirculation
Microvessels
/ diagnostic imaging
Middle Aged
Moyamoya Disease
/ diagnostic imaging
Neurites
/ pathology
Neuropsychological Tests
Positron-Emission Tomography
Predictive Value of Tests
Severity of Illness Index
Young Adult
Moyamoya disease
cerebral blood flow and metabolism
cognition
cognitive impairment
diffusion MRI
ischemia
magnetic resonance imaging
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
09
09
2018
revised:
04
12
2018
accepted:
27
12
2018
pubmed:
27
1
2019
medline:
10
4
2019
entrez:
26
1
2019
Statut:
ppublish
Résumé
Chronic ischemia may induce brain microstructural damage and lead to neurocognitive dysfunction in patients with Moyamoya disease (MMD). We applied neurite orientation dispersion and density imaging (NODDI) and Thirty-one patients (16-63years old, 9 males) and 20 age- and sex-matched normal controls were enrolled in this study. NODDI evaluates quantitative parameters reflecting neurite and axonal density, network complexity and the interstitial fluid in all participants. Of 31 patients, 12 newly diagnosed patients were evaluated with PET, also. We evaluated correlations between the microstructural parameters of NODDI and the hemodynamic and metabolic parameters of PET, the relationship between NODDI and clinical severity of each hemisphere (Normal, Asymtpomatic, Symptomatic, and Infarcted) as well as neurocognitive performance. All NODDI parameters significantly correlated with PET parameters (absolute r = 0.46-0.83, P ≤ .048) and clinical severity (P < .001), suggesting that neurite and axonal density and network complexity decreased, and the interstitial fluid increased, as the ischemic burden became severe. NODDI parameters reflecting neurite and axonal density and network complexity significantly correlated with neurocognitive profiles (r = 0.36-0.64, P ≤ .048), but the interstitial fluid component did not. Chronic ischemia in patients with MMD may induce decreased neurite and axonal density, simplified network complexity, and may lead to neurocognitive dysfunction. The increased interstitial fluid accompanying hemodynamic impairment may not be identical to the decreased neurite density and might be driven by another mechanism.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
Chronic ischemia may induce brain microstructural damage and lead to neurocognitive dysfunction in patients with Moyamoya disease (MMD). We applied neurite orientation dispersion and density imaging (NODDI) and
MATERIALS AND METHODS
METHODS
Thirty-one patients (16-63years old, 9 males) and 20 age- and sex-matched normal controls were enrolled in this study. NODDI evaluates quantitative parameters reflecting neurite and axonal density, network complexity and the interstitial fluid in all participants. Of 31 patients, 12 newly diagnosed patients were evaluated with PET, also. We evaluated correlations between the microstructural parameters of NODDI and the hemodynamic and metabolic parameters of PET, the relationship between NODDI and clinical severity of each hemisphere (Normal, Asymtpomatic, Symptomatic, and Infarcted) as well as neurocognitive performance.
RESULTS
RESULTS
All NODDI parameters significantly correlated with PET parameters (absolute r = 0.46-0.83, P ≤ .048) and clinical severity (P < .001), suggesting that neurite and axonal density and network complexity decreased, and the interstitial fluid increased, as the ischemic burden became severe. NODDI parameters reflecting neurite and axonal density and network complexity significantly correlated with neurocognitive profiles (r = 0.36-0.64, P ≤ .048), but the interstitial fluid component did not.
CONCLUSIONS
CONCLUSIONS
Chronic ischemia in patients with MMD may induce decreased neurite and axonal density, simplified network complexity, and may lead to neurocognitive dysfunction. The increased interstitial fluid accompanying hemodynamic impairment may not be identical to the decreased neurite density and might be driven by another mechanism.
Identifiants
pubmed: 30679013
pii: S1052-3057(18)30738-9
doi: 10.1016/j.jstrokecerebrovasdis.2018.12.038
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1113-1125Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.