Antenatal Glucocorticoid Exposure Results in Sex-Specific and Transgenerational Changes in Prefrontal Cortex Gene Transcription that Relate to Behavioural Outcomes.
Adult
Calbindin 1
/ genetics
Female
Gene Expression Regulation, Developmental
/ drug effects
Glucocorticoids
/ administration & dosage
Humans
Infant, Newborn
Locomotion
/ drug effects
Male
Prefrontal Cortex
/ drug effects
Premature Birth
/ drug therapy
Receptors, G-Protein-Coupled
/ genetics
Receptors, Glycine
/ genetics
Respiratory Distress Syndrome, Newborn
/ drug therapy
Sex Characteristics
Stress, Physiological
/ drug effects
Transcription, Genetic
/ drug effects
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 01 2019
24 01 2019
Historique:
received:
28
02
2018
accepted:
28
11
2018
entrez:
26
1
2019
pubmed:
27
1
2019
medline:
25
7
2020
Statut:
epublish
Résumé
Synthetic glucocorticoids (sGC) are administered to women at risk for pre-term delivery to reduce respiratory distress syndrome in the newborn. The prefrontal cortex (PFC) is important in regulating stress responses and related behaviours and expresses high levels of glucocorticoid receptors (GR). Further, antenatal exposure to sGC results in a hyperactive phenotype in first generation (F
Identifiants
pubmed: 30679753
doi: 10.1038/s41598-018-37088-3
pii: 10.1038/s41598-018-37088-3
pmc: PMC6346022
doi:
Substances chimiques
CALB1 protein, human
0
Calbindin 1
0
GPR52 protein, human
0
Glucocorticoids
0
Receptors, G-Protein-Coupled
0
Receptors, Glycine
0
glycine receptor alpha3 subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
764Subventions
Organisme : CIHR
ID : MOP-126166
Pays : Canada
Organisme : CIHR
ID : FDN-148368
Pays : Canada
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