Computing the Pathogenicity of Alzheimer's Disease Presenilin 1 Mutations.
Journal
Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060
Informations de publication
Date de publication:
25 02 2019
25 02 2019
Historique:
pubmed:
27
1
2019
medline:
9
1
2020
entrez:
26
1
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is one of the major global health challenges of the 21st century. More than 200 distinct mutations in presenilin 1 (PSEN1) cause severe early-onset familial AD (FAD) and are thus of central interest to the etiology of AD. PSEN1 is the catalytic subunit of γ-secretase that produces β-amyloid peptide (Aβ), and the mutations tend to increase the produced Aβ
Identifiants
pubmed: 30681848
doi: 10.1021/acs.jcim.8b00896
doi:
Substances chimiques
Amyloid beta-Peptides
0
Presenilin-1
0
Amyloid Precursor Protein Secretases
EC 3.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM