Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.
Behavioral epigenetics
DNA methylation
Estrogen sensitivity
Maternal behavior
Oxytocin
Pregnancy
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
06
2018
revised:
11
01
2019
accepted:
12
01
2019
pubmed:
29
1
2019
medline:
24
4
2020
entrez:
29
1
2019
Statut:
ppublish
Résumé
Maternal behavior (MB) is observable across mammals and represents an important feature of environmental variation during early postnatal development. Oxytocin (OT) plays a crucial role in MB. Even prior to childbirth, pregnancy induces epigenetic and other downstream changes in the maternal OT-system, likely mediated by the actions of steroid hormones. However, little is known about the nature and consequences of epigenetic modifications in the maternal OT-encoding gene (OXT) during pregnancy. Our study aims to investigate temporal dynamics of OXT promoter DNA methylation (DNAm) throughout pregnancy in predicting MB in humans. In 107 mother-child dyads, maternal OXT DNAm was serially analyzed in whole blood in early, mid and late pregnancy. MB was coded based on standardized mother-child interactions at six months postpartum. After controlling for cellular heterogeneity, race/ethnicity, age, and socioeconomic status, OXT-promoter DNAm exhibited a dynamic profile during pregnancy (b = 0.026, t=-3.37, p < .001), with decreases in DNAm from early to mid-pregnancy and no further change until late pregnancy. Moreover, dynamic DNAm trajectories of the OXT-promoter region predicted MB (intrusiveness) at six months postpartum (b = 0.006, t = 2.0, p < 0.05), with 6% higher OXT DNAm in late pregnancy in intrusive compared to non-intrusive mothers. We here demonstrate that OXT promoter DNAm changes significantly throughout gestation in peripheral blood and that these changes are associated with variability in MB, providing a novel potential biomarker predicting postnatal MB.
Identifiants
pubmed: 30690225
pii: S0306-4530(18)30554-7
doi: 10.1016/j.psyneuen.2019.01.013
pmc: PMC6554513
mid: NIHMS1023923
pii:
doi:
Substances chimiques
Receptors, Oxytocin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
156-162Subventions
Organisme : NICHD NIH HHS
ID : R01 HD060628
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH091351
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105538
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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