Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer.

Adenocarcinoma / genetics Adenocarcinoma, Mucinous / genetics Appendiceal Neoplasms / genetics Biomarkers, Tumor / genetics Chromogranins / genetics Colorectal Neoplasms / genetics Female GTP-Binding Protein alpha Subunits, Gs / genetics Gene Expression Profiling High-Throughput Nucleotide Sequencing / methods Humans Male Microsatellite Instability Mutation Proto-Oncogene Proteins p21(ras) / genetics Pseudomyxoma Peritonei / genetics Retrospective Studies

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 05 2019
Historique:
received: 15 10 2018
revised: 18 11 2018
accepted: 18 01 2019
pubmed: 30 1 2019
medline: 17 7 2020
entrez: 30 1 2019
Statut: ppublish

Résumé

The natural history and prognosis of appendiceal adenocarcinomas differ from those of adenocarcinomas arising in other large bowel sites. We aimed to compare the molecular profiles exhibited by appendiceal adenocarcinomas and colorectal cancers, or between the histopathologic subtypes of appendiceal adenocarcinoma. A total of 183 samples from appendiceal adenocarcinoma [46 adenocarcinoma, not otherwise specified (NOS), 66 pseudomyxoma peritonei (PMP), 44 mucinous adenocarcinoma (MU), and 27 signet ring cell carcinoma (SR)], 994 from right-sided colorectal cancer (R-CRC), and 1,080 from left-sided CRC (L-CRC) were analyzed by next-generation sequencing (NGS) and IHC markers. Microsatellite instability (MSI) and tumor mutational burden (TMB) were tested by NGS, and programmed death ligand 1 (PD-L1) by IHC. We observed high mutation rates in appendiceal adenocarcinoma samples for Molecular profiling of appendiceal adenocarcinoma revealed different molecular characteristics than noted in R-CRC and L-CRC, and molecular heterogeneity among the histopathologic subtypes of appendiceal adenocarcinoma. Our findings may be critical to developing an individualized approach to appendiceal adenocarcinoma treatment.

Identifiants

DOI: 10.1158/1078-0432.CCR-18-3388 PMID: 30692096 PMC: PMC6886223
pubmed: 30692096
pii: 1078-0432.CCR-18-3388
doi: 10.1158/1078-0432.CCR-18-3388
pmc: PMC6886223
mid: NIHMS1519705
doi:

Substances chimiques

Biomarkers, Tumor 0
Chromogranins 0
KRAS protein, human 0
GNAS protein, human EC 3.6.1.-
GTP-Binding Protein alpha Subunits, Gs EC 3.6.5.1
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3096-3103

Subventions

Organisme : NCI NIH HHS
ID : P30 CA014089
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA022453
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Ryuma Tokunaga (R)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California. rtokunag@usc.edu.

Joanne Xiu (J)

Caris Life Sciences, Phoenix, Arizona.

Curtis Johnston (C)

Caris Life Sciences, Phoenix, Arizona.

Richard M Goldberg (RM)

West Virginia University Cancer Institute, Morgantown, West Virginia.
ORCID: 0000-0003-0308-8223

Philip A Philip (PA)

Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.

Andreas Seeber (A)

Department of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria.

Madiha Naseem (M)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Jae Ho Lo (JH)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Hiroyuki Arai (H)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Francesca Battaglin (F)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Alberto Puccini (A)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.
ORCID: 0000-0002-2492-4043

Martin D Berger (MD)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Shivani Soni (S)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Wu Zhang (W)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Jimmy J Hwang (JJ)

Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina.

Anthony F Shields (AF)

Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan.

John L Marshall (JL)

Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C.

Hideo Baba (H)

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

W Michael Korn (WM)

Caris Life Sciences, Phoenix, Arizona.

Heinz-Josef Lenz (HJ)

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs kystiques, mucineuses et séreuses › Adénocarcinome mucineux › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du caecum › Tumeurs de l'appendice › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Chromogranine › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines G hétérotrimériques › Sous-unités alpha des protéines G › Sous-unités alpha Gs des protéines G › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des microsatellites › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs kystiques, mucineuses et séreuses › Adénocarcinome mucineux › Pseudomyxome péritonéal › Molecular Profiling of Appendiceal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Molecular Profiling of Appendiceal...