Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H.

Alkaloids / chemistry Lycopodium / chemistry Magnetic Resonance Spectroscopy

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
22 02 2019
Historique:
pubmed: 31 1 2019
medline: 9 4 2020
entrez: 31 1 2019
Statut: ppublish

Résumé

Three new Lycopodium alkaloids comprising two lycodine-type alkaloids (1, 2) and one fawcettimine alkaloid (3), in addition to 16 known alkaloids, were isolated from Lycopodium platyrhizoma. The structures of these alkaloids were elucidated based on analysis of their NMR and MS data. Lycoplatyrine A (1) represents an unusual lycodine-piperidine adduct. The structures and absolute configurations of lycoplanine D (hydroxy-des- N-methyl-α-obscurine, 10) and lycogladine H (11) were confirmed by X-ray diffraction analysis.

Identifiants

DOI: 10.1021/acs.jnatprod.8b00754 PMID: 30698428
pubmed: 30698428
doi: 10.1021/acs.jnatprod.8b00754
doi:

Substances chimiques

Alkaloids 0
lycoplanine D 0
lycoplatyrine A 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

324-329

Auteurs

Joanne Soon-Yee Yeap (JS)

Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.

Kuan-Hon Lim (KH)

School of Pharmacy , University of Nottingham Malaysia Campus , Jalan Broga , 43500 Semenyih , Selangor , Malaysia.
ORCID: 0000-0003-1462-3324

Kien-Thai Yong (KT)

Institute of Biological Sciences, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.

Siew-Huah Lim (SH)

Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.

Toh-Seok Kam (TS)

Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.
ORCID: 0000-0002-4910-6434

Yun-Yee Low (YY)

Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.
ORCID: 0000-0002-7429-4238

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Lycopodium Alkaloids: Lycoplatyrine A, an...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Lycopodiaceae › Lycopodium › Lycopodium Alkaloids: Lycoplatyrine A, an...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Lycopodium Alkaloids: Lycoplatyrine A, an...