Intrinsic brain abnormalities in drug-naive patients with obsessive-compulsive disorder: A resting-state functional MRI study.
Adult
Brain
/ diagnostic imaging
Brain Mapping
Corpus Striatum
/ diagnostic imaging
Female
Frontal Lobe
/ diagnostic imaging
Humans
Limbic System
/ diagnostic imaging
Magnetic Resonance Imaging
/ methods
Male
Neural Pathways
/ diagnostic imaging
Obsessive-Compulsive Disorder
/ diagnostic imaging
Psychiatric Status Rating Scales
Thalamus
/ diagnostic imaging
Young Adult
Drug-naive
Fractional amplitude of low-frequency fluctuation
Functional connectivity
Obsessive-compulsive disorder
Resting-state fMRI
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
27
05
2018
revised:
14
10
2018
accepted:
11
11
2018
entrez:
1
2
2019
pubmed:
1
2
2019
medline:
2
4
2019
Statut:
ppublish
Résumé
Using the resting-state functional magnetic resonance imaging (rs-fMRI) in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD), the current study aims to explore alterations in regional and network-level neural function and to determine the association between these alterations in intrinsic neural activity and symptom severity in OCD. A total of 68 drug-naive OCD patients and 68 healthy control subjects (HCS) were examined using rs-fMRI. Regional cerebral function was evaluated by measuring the fraction of amplitude of low-frequency fluctuation (fALFF). Regions with fALFF alterations were used as seeds in whole-brain functional connectivity (FC) analysis. Statistical analyses of fALFF and FC differences between OCD patients with HCS were performed voxel-by-voxel using a two-sample t-test in Statistical Parametric Mapping version 8 (SPM8). Whole brain correlation analyses were performed to identify the association between functional neural correlates and OCD symptom severity evaluated using Yale-Brown Obsessive Compulsive scale (Y-BOCS) and subscale scores. Relative to HCS, OCD patients showed higher fALFF in the right putamen and right superior frontal gyrus (P < 0.05, corrected for AlphaSim); higher FC in the limbic-striatal circuit and lower FC in the fronto-temporal and fronto-striato-thalamic networks (P < 0.05, corrected for AlphaSim). FC in striato-thalamic junction was negatively correlated with the Y-BOCS total score (r = -0.493, P < 0.001). These findings of focal spontaneous hyperfunction confirmed the prevailing frontal-striatal model of OCD, and altered brain connectivity in large-scale resting-state networks indicated a connectivity-based pathophysiological process in OCD.
Sections du résumé
BACKGROUND
Using the resting-state functional magnetic resonance imaging (rs-fMRI) in a relatively large sample of drug-naive patients with obsessive-compulsive disorder (OCD), the current study aims to explore alterations in regional and network-level neural function and to determine the association between these alterations in intrinsic neural activity and symptom severity in OCD.
METHODS
A total of 68 drug-naive OCD patients and 68 healthy control subjects (HCS) were examined using rs-fMRI. Regional cerebral function was evaluated by measuring the fraction of amplitude of low-frequency fluctuation (fALFF). Regions with fALFF alterations were used as seeds in whole-brain functional connectivity (FC) analysis. Statistical analyses of fALFF and FC differences between OCD patients with HCS were performed voxel-by-voxel using a two-sample t-test in Statistical Parametric Mapping version 8 (SPM8). Whole brain correlation analyses were performed to identify the association between functional neural correlates and OCD symptom severity evaluated using Yale-Brown Obsessive Compulsive scale (Y-BOCS) and subscale scores.
RESULTS
Relative to HCS, OCD patients showed higher fALFF in the right putamen and right superior frontal gyrus (P < 0.05, corrected for AlphaSim); higher FC in the limbic-striatal circuit and lower FC in the fronto-temporal and fronto-striato-thalamic networks (P < 0.05, corrected for AlphaSim). FC in striato-thalamic junction was negatively correlated with the Y-BOCS total score (r = -0.493, P < 0.001).
CONCLUSION
These findings of focal spontaneous hyperfunction confirmed the prevailing frontal-striatal model of OCD, and altered brain connectivity in large-scale resting-state networks indicated a connectivity-based pathophysiological process in OCD.
Identifiants
pubmed: 30699871
pii: S0165-0327(18)31147-9
doi: 10.1016/j.jad.2018.11.080
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
861-868Informations de copyright
Copyright © 2018. Published by Elsevier B.V.