Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

Animals Atherosclerosis / genetics Cardiovascular Diseases / genetics Disease Models, Animal Disease Progression Eating Enterocytes / cytology Female Glucagon-Like Peptide 1 / metabolism Glucagon-Like Peptide-1 Receptor / metabolism Integrin beta Chains / genetics Intestine, Small / cytology Intraepithelial Lymphocytes / metabolism Male Metabolic Syndrome / genetics Mice

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2019
Historique:
received: 01 12 2017
accepted: 05 12 2018
pubmed: 1 2 2019
medline: 25 7 2019
entrez: 1 2 2019
Statut: ppublish

Résumé

The biochemical response to food intake must be precisely regulated. Because ingested sugars and fats can feed into many anabolic and catabolic pathways

Identifiants

DOI: 10.1038/s41586-018-0849-9 PMID: 30700910 PMC: PMC6367023
pubmed: 30700910
doi: 10.1038/s41586-018-0849-9
pii: 10.1038/s41586-018-0849-9
pmc: PMC6367023
mid: NIHMS1515990
doi:

Substances chimiques

Glp1r protein, mouse 0
Glucagon-Like Peptide-1 Receptor 0
Integrin beta Chains 0
integrin beta7 0
Glucagon-Like Peptide 1 89750-14-1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

115-119

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL131478
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128264
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135752
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI118692
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Références

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Auteurs

Shun He (S)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. SHE6@mgh.harvard.edu.

Florian Kahles (F)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Sara Rattik (S)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Manfred Nairz (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Cameron S McAlpine (CS)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Atsushi Anzai (A)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Daniel Selgrade (D)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Ashley M Fenn (AM)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Christopher T Chan (CT)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

John E Mindur (JE)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Colin Valet (C)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Wolfram C Poller (WC)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Lennard Halle (L)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Noemi Rotllan (N)

Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA.

Yoshiko Iwamoto (Y)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Gregory R Wojtkiewicz (GR)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Ralph Weissleder (R)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Peter Libby (P)

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Carlos Fernández-Hernando (C)

Vascular Biology and Therapeutics Program, Department of Comparative Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA.

Daniel J Drucker (DJ)

Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Matthias Nahrendorf (M)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Filip K Swirski (FK)

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. fswirski@mgh.harvard.edu.
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. fswirski@mgh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Maladies cardiovasculaires › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Consommation alimentaire › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Cellules › Cellules épithéliales › Entérocytes › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone gastrointestinale › Récepteurs des peptides similaires au glucagon › Récepteur du peptide-1 similaire au glucagon › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Chaines bêta des intégrines › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Intestin grêle › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes intra-épithéliaux › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Gut intraepithelial T cells calibrate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Gut intraepithelial T cells calibrate...