Alternative splicing of neuronal genes: new mechanisms and new therapies.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
19
12
2018
accepted:
27
12
2018
pubmed:
1
2
2019
medline:
12
2
2020
entrez:
1
2
2019
Statut:
ppublish
Résumé
Dynamic changes in alternative splicing during the life cycle of neurons support development and plasticity, and are implicated in disease pathology. Cell-specific alternative splicing programs coordinate exon selection across networks of functionally connected genes. In this opinion piece, we highlight recent publications that identify some of the molecular mechanisms-RNA and DNA binding proteins and epigenetic modifications-which direct cell-specific exon selection during pre-mRNA splicing. Aberrant splicing patterns are signature features of a growing number of diseases of the nervous system. Recent publications demonstrate the value of delineating basic mechanisms that dictate exon choice to inform the development of new therapeutic strategies that correct or compensate for damaging deficits in alternative splicing.
Identifiants
pubmed: 30703685
pii: S0959-4388(18)30187-9
doi: 10.1016/j.conb.2018.12.013
pmc: PMC6629480
mid: NIHMS1519793
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
26-31Subventions
Organisme : NINDS NIH HHS
ID : R01 NS055251
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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