FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Aged C9orf72 Protein / genetics Cerebellum / diagnostic imaging Female Fluorodeoxyglucose F18 Frontotemporal Lobar Degeneration / diagnostic imaging Humans Male Middle Aged Mutation Positron-Emission Tomography Sensitivity and Specificity Thalamus / diagnostic imaging

Journal

Translational psychiatry

ISSN: 2158-3188

Titre abrégé: Transl Psychiatry

Pays: United States

ID NLM: 101562664

Informations de publication

Date de publication:
31 01 2019

Historique:

received: 16 05 2018

accepted: 01 01 2019

revised: 05 12 2018

entrez: 2 2 2019

pubmed: 2 2 2019

medline: 14 6 2019

Statut: epublish

Résumé

C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter,

Identifiants

DOI: 10.1038/s41398-019-0381-1 PMID: 30705258 PMC: PMC6355852

pubmed: 30705258

doi: 10.1038/s41398-019-0381-1

pii: 10.1038/s41398-019-0381-1

pmc: PMC6355852

doi:

Substances chimiques

C9orf72 Protein 0

C9orf72 protein, human 0

Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

Investigateurs

Nibal Ackl (N)

Christine V Arnim (CV)

Joachim Brumberg (J)

Florian Gärtner (F)

Holger Jahn (H)

Elisabeth Kasper (E)

Jan Kassubek (J)

Catharina Prix (C)

Lina Riedl (L)

Carola Roßmeier (C)

Sonja Schönecker (S)

Elisa Semler (E)

Stefan Teipel (S)

Christine Westerteicher (C)

Elisabeth Wlasich (E)

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