Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents.
Adolescent
Alcohol use disorder
Anterior cingulate cortex
Cannabis use disorder
Striatum
fMRI
Journal
Developmental cognitive neuroscience
ISSN: 1878-9307
Titre abrégé: Dev Cogn Neurosci
Pays: Netherlands
ID NLM: 101541838
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
07
06
2018
revised:
11
01
2019
accepted:
19
01
2019
pubmed:
3
2
2019
medline:
16
11
2019
entrez:
3
2
2019
Statut:
ppublish
Résumé
Alcohol and cannabis are two of the most commonly used substances by adolescents and are associated with adverse medical and psychiatric outcomes. These adverse psychiatric outcomes may reflect the negative impact of alcohol and/or cannabis abuse on neural systems mediating reward and/or error detection. However, work indicative of this has mostly been conducted in adults with Alcohol and/or Cannabis Use Disorder (i.e., AUD and CUD), with relatively little work in adolescent patients. Furthermore, of the work that has been conducted in adolescents, groups were based on categorical diagnoses of AUD and/or CUD, so the relationship between AUD and/or CUD symptom severity in adolescents and neural dysfunction is unclear. We used a Monetary Incentive Delay (MID) task to examine the relationship between AUDIT and/or CUDIT scores and functional integrity of neuro-circuitries mediating reward processing and error detection within 150 adolescents. Our findings indicate that AUDIT score is negatively related to activity in reward processing neuro-circuitry in adolescents. However, CUDIT score is negatively related to activity in brain regions involved in error detection. Each of these relationships reflected a medium effect size (Partial-η
Identifiants
pubmed: 30710868
pii: S1878-9293(18)30130-0
doi: 10.1016/j.dcn.2019.100618
pmc: PMC6613939
mid: NIHMS1033308
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100618Subventions
Organisme : NIMH NIH HHS
ID : K01 MH110643
Pays : United States
Organisme : NIMH NIH HHS
ID : K22 MH109558
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM115458
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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