Different Effects on Fluid Distribution between Tolvaptan and Furosemide in a Liver Cirrhosis Patient with Chronic Kidney Disease.
Aged
Antidiuretic Hormone Receptor Antagonists
/ pharmacology
Benzazepines
/ pharmacology
Diuretics
/ pharmacology
Drug Therapy, Combination
Edema
/ drug therapy
Fluid Shifts
/ drug effects
Furosemide
/ pharmacology
Humans
Leg
Liver Cirrhosis
/ complications
Male
Renal Insufficiency, Chronic
/ complications
Tolvaptan
/ pharmacology
bioimpedance analysis
extracellular water
furosemide
intracellular water
liver cirrhosis
tolvaptan
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
01 Jun 2019
01 Jun 2019
Historique:
pubmed:
5
2
2019
medline:
14
8
2019
entrez:
5
2
2019
Statut:
ppublish
Résumé
A 73-year-old man with liver cirrhosis and advanced chronic kidney disease was admitted to our hospital due to bilateral lower leg edema and appetite loss. Furosemide to treat fluid retention markedly decreased extracellular water compared with intracellular water, but the addition of tolvaptan equally decreased both with a greater diuretic response than furosemide alone. Furthermore, tolvaptan administration increased the plasma colloid osmotic pressure, which might facilitate the shift of fluid from the extravascular space to the intravascular space. This is the first case showing different effects on the fluid distribution between furosemide and additional tolvaptan in the same patient.
Identifiants
pubmed: 30713322
doi: 10.2169/internalmedicine.2174-18
pmc: PMC6599930
doi:
Substances chimiques
Antidiuretic Hormone Receptor Antagonists
0
Benzazepines
0
Diuretics
0
Tolvaptan
21G72T1950
Furosemide
7LXU5N7ZO5
Types de publication
Case Reports
Journal Article
Langues
eng
Pagination
1587-1591Références
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