Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior.
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
16
11
2018
revised:
21
01
2019
accepted:
27
01
2019
pubmed:
5
2
2019
medline:
4
1
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Dopamine D2 receptors (D2Rs) mediate many of the actions of dopamine in the striatum, ranging from movement to the effortful pursuit of reward. Yet despite significant advances in linking D2Rs to striatal functions with pharmacological and genetic strategies in animals, how dopamine orchestrates its myriad actions on different cell populations -each expressing D2Rs- remains unclear. Furthermore, brain imaging and genetic studies in humans have consistently associated striatal D2R alterations with various neurological and neuropsychiatric disorders, but how and which D2Rs are involved in each case is poorly understood. Therefore, a critical first step is to engage in a refined and systematic investigation of the impact of D2R function on specific striatal cells, circuits, and behaviors. Here, I will review recent efforts, primarily in animal models, aimed at unlocking the complex and heterogeneous roles of D2Rs in striatum.
Identifiants
pubmed: 30716356
pii: S0197-0186(18)30633-8
doi: 10.1016/j.neuint.2019.01.022
pmc: PMC6450565
mid: NIHMS1521770
pii:
doi:
Substances chimiques
Dopamine Agents
0
Receptors, Dopamine D2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-46Subventions
Organisme : NIMH NIH HHS
ID : K01 MH107648
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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