The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.
C9orf72
Chronnectome
Dynamic brain functional connectivity
Frontotemporal dementia
Granulin
Microtuble associate protein tau
Mutation
resting-state fMRI
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
17
10
2018
revised:
27
01
2019
accepted:
31
01
2019
pubmed:
5
2
2019
medline:
25
1
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 472 at-risk FTD subjects from the Genetic Frontotemporal dementia research Initiative (GENFI) cohort. We considered 249 subjects with FTD-related pathogenetic mutations and 223 mutation non-carriers (HC). Dynamic connectivity was evaluated using independent component analysis and sliding-time window correlation to rs-fMRI data, and meta-state measures of global brain flexibility were extracted. Results show that presymptomatic FTD exhibits diminished dynamic fluidity, visiting less meta-states, shifting less often across them, and travelling through a narrowed meta-state distance, as compared to HC. Dynamic connectivity changes characterize preclinical FTD, arguing for the desynchronization of the inner fluctuations of the brain. These changes antedate clinical symptoms, and might represent an early signature of FTD to be used as a biomarker in clinical trials.
Identifiants
pubmed: 30716457
pii: S1053-8119(19)30086-2
doi: 10.1016/j.neuroimage.2019.01.080
pmc: PMC6669888
mid: NIHMS1042599
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
645-654Subventions
Organisme : Medical Research Council
ID : G1100464
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R35 NS097261
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00024/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : R01 EB006841
Pays : United States
Organisme : Medical Research Council
ID : MC_U105597119
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J009482/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M023664/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K010395/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008525/1
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : P20 GM103472
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118695
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB020407
Pays : United States
Organisme : Medical Research Council
ID : MR/M009106/1
Pays : United Kingdom
Investigateurs
Maria Rosario Almeida
(MR)
Sarah Anderl-Straub
(S)
Christin Andersson
(C)
Anna Antonell
(A)
Andrea Arighi
(A)
Mircea Balasa
(M)
Myriam Barandiaran
(M)
Nuria Bargalló
(N)
Robart Bartha
(R)
Benjamin Bender
(B)
Luisa Benussi
(L)
Giuliano Binetti
(G)
Sandra Black
(S)
Martina Bocchetta
(M)
Sergi Borrego-Ecija
(S)
Jose Bras
(J)
Rose Bruffaerts
(R)
Paola Caroppo
(P)
David Cash
(D)
Miguel Castelo-Branco
(M)
Rhian Convery
(R)
Thomas Cope
(T)
María de Arriba
(M)
Giuseppe Di Fede
(G)
Zigor Díaz
(Z)
Katrina M Dick
(KM)
Diana Duro
(D)
Chiara Fenoglio
(C)
Carlos Ferreira
(C)
Catarina B Ferreira
(CB)
Toby Flanagan
(T)
Nick Fox
(N)
Morris Freedman
(M)
Giorgio Fumagalli
(G)
Alazne Gabilondo
(A)
Serge Gauthier
(S)
Roberta Ghidoni
(R)
Giorgio Giaccone
(G)
Ana Gorostidi
(A)
Caroline Greaves
(C)
Rita Guerreiro
(R)
Carolin Heller
(C)
Tobias Hoegen
(T)
Begoña Indakoetxea
(B)
Vesna Jelic
(V)
Lize Jiskoot
(L)
Hans-Otto Karnath
(HO)
Ron Keren
(R)
Maria João Leitão
(MJ)
Albert Lladó
(A)
Gemma Lombardi
(G)
Sandra Loosli
(S)
Carolina Maruta
(C)
Simon Mead
(S)
Lieke Meeter
(L)
Gabriel Miltenberger
(G)
Rick van Minkelen
(R)
Sara Mitchell
(S)
Benedetta Nacmias
(B)
Mollie Neason
(M)
Jennifer Nicholas
(J)
Linn Öijerstedt
(L)
Jaume Olives
(J)
Jessica Panman
(J)
Janne Papma
(J)
Maximilian Patzig
(M)
Michela Pievani
(M)
Sara Prioni
(S)
Catharina Prix
(C)
Rosa Rademakers
(R)
Veronica Redaelli
(V)
Tim Rittman
(T)
Ekaterina Rogaeva
(E)
Pedro Rosa-Neto
(P)
Giacomina Rossi
(G)
Martin Rossor
(M)
Beatriz Santiago
(B)
Elio Scarpini
(E)
Elisa Semler
(E)
Rachelle Shafei
(R)
Christen Shoesmith
(C)
Miguel Tábuas-Pereira
(M)
Mikel Tainta
(M)
David Tang-Wai
(D)
David L Thomas
(DL)
Hakan Thonberg
(H)
Carolyn Timberlake
(C)
Pietro Tiraboschi
(P)
Philip Vandamme
(P)
Mathieu Vandenbulcke
(M)
Michele Veldsman
(M)
Ana Verdelho
(A)
Jorge Villanua
(J)
Jason Warren
(J)
Carlo Wilke
(C)
Henrik Zetterberg
(H)
Miren Zulaica
(M)
Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
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