Cellular antioxidant activity and in vitro inhibition of α-glucosidase, α-amylase and pancreatic lipase of oregano polyphenols under simulated gastrointestinal digestion.
Antioxidants
/ isolation & purification
Caco-2 Cells
Chromatography, High Pressure Liquid
Digestion
Gastric Acid
/ chemistry
Glycoside Hydrolase Inhibitors
/ isolation & purification
Humans
Hypolipidemic Agents
/ isolation & purification
Intestinal Secretions
/ chemistry
Lipase
/ antagonists & inhibitors
Origanum
/ chemistry
Oxidation-Reduction
Oxidative Stress
/ drug effects
Plant Extracts
/ isolation & purification
Polyphenols
/ isolation & purification
Spectrometry, Mass, Electrospray Ionization
Bioavailability
Gastrointestinal digestion
Hedeoma patens
Lippia graveolens
Lippia palmeri
Polyphenols
Journal
Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
10
06
2018
revised:
25
08
2018
accepted:
30
08
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
6
2
2020
Statut:
ppublish
Résumé
Different oregano species have been traditionally used as infusions in folk medicine. Oregano medicinal properties, such as antioxidant and anti-inflammatory, have been partially attributed to its polyphenolic content. However, information regarding bioaccessibility of oregano polyphenols is limited. Cell-based antioxidant activity, and in vitro hypoglycemic, and hypolipidemic properties of polyphenolic extracts from three species of oregano species, namely, Hedeoma patens (HP), Lippia graveolens (LG) and Lippia palmeri (LP), subjected to simulated gastrointestinal digestion were evaluated. LC-TOF-MS analysis of HP, LG and LP allowed the identification of 9 flavonoids and 6 hydroxycinnamic acid derivatives with nutraceutical significance. Oregano polyphenolic extracts and digests from HP, LG, and LP exhibited cellular antioxidant capacity, hypoglycemic and hypolipidemic properties. Altogether, our results suggest that HP, LG and LP polyphenols exhibit potential for use as hypoglycemic, hypolipidemic, and antioxidant agents.
Identifiants
pubmed: 30716995
pii: S0963-9969(18)30711-7
doi: 10.1016/j.foodres.2018.08.096
pii:
doi:
Substances chimiques
Antioxidants
0
Glycoside Hydrolase Inhibitors
0
Hypolipidemic Agents
0
Plant Extracts
0
Polyphenols
0
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
676-686Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.