Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from

ADAM17 Protein / antagonists & inhibitors Alzheimer Disease / drug therapy Amyloid Precursor Protein Secretases / antagonists & inhibitors Aspartic Acid Endopeptidases / antagonists & inhibitors Benzofurans / chemistry Cholinesterase Inhibitors / pharmacology Cholinesterases / chemistry Dioxins / chemistry Molecular Docking Simulation Seaweed / chemistry Tannins / chemistry
Alzheimer′s disease BACE1 acetylcholinesterase in silico docking phlorotannins

Journal

Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729

Informations de publication

Date de publication:
01 Feb 2019
Historique:
received: 08 01 2019
revised: 24 01 2019
accepted: 28 01 2019
entrez: 6 2 2019
pubmed: 6 2 2019
medline: 27 4 2019
Statut: epublish

Résumé

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases with a multifactorial nature. β-Secretase (BACE1) and acetylcholinesterase (AChE), which are required for the production of neurotoxic β-amyloid (Aβ) and the promotion of Aβ fibril formation, respectively, are considered as prime therapeutic targets for AD. In our efforts towards the development of potent multi-target, directed agents for AD treatment, major phlorotannins such as eckol, dieckol, and 8,8'-bieckol from

Identifiants

DOI: 10.3390/md17020091 PMID: 30717208 PMC: PMC6410325
pubmed: 30717208
pii: md17020091
doi: 10.3390/md17020091
pmc: PMC6410325
pii:
doi:

Substances chimiques

Benzofurans 0
Cholinesterase Inhibitors 0
Dioxins 0
Tannins 0
dieckol 0
eckol 88798-74-7
8,8'-bieckol 89445-12-5
Cholinesterases EC 3.1.1.8
Amyloid Precursor Protein Secretases EC 3.4.-
Aspartic Acid Endopeptidases EC 3.4.23.-
BACE1 protein, human EC 3.4.23.46
ADAM17 Protein EC 3.4.24.86
ADAM17 protein, human EC 3.4.24.86

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Dong-A University
ID : None

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Auteurs

Jinhyuk Lee (J)

Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125, Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea. jinhyuk@kribb.re.kr.
Department of Bioinformatics, KIRBB School of Bioscience, Korea University of Sciences and Technology, 217 Gajung-ro, Yuseong-gu, Daejeon 34113, Korea. jinhyuk@kribb.re.kr.

Mira Jun (M)

Department of Food Science and Nutrition, College of Health Sciences, Dong-A University, 37, Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Korea. mjun@dau.ac.kr.
Center for Silver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Korea. mjun@dau.ac.kr.
Institute of Convergence Bio-Health, Dong-A University, Busan 49315, Korea. mjun@dau.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéines ADAM › Protéine ADAM17 › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Amyloid precursor protein secretases › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Dioxines › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Stades d'organismes › Algue marine › Dual BACE1 and Cholinesterase Inhibitory...
questionsmedicales.fr › Structures macromoléculaires › Tanins › Dual BACE1 and Cholinesterase Inhibitory...