Exploring the genetics of trotting racing ability in horses using a unique Nordic horse model.
Athleticism
Conformation
Genomic
Performance
Racehorse
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
04 Feb 2019
04 Feb 2019
Historique:
received:
19
09
2018
accepted:
28
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
21
5
2019
Statut:
epublish
Résumé
Horses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great deal of variation still exists between breeds, making the horse particularly well suited for genetic studies of athleticism. To identify genomic regions associated with athleticism as it pertains to trotting racing ability in the horse, the current study applies a pooled sequence analysis approach using a unique Nordic horse model. Pooled sequence data from three Nordic horse populations were used for F Not unexpected for genomic investigations of complex traits, the current study identified hundreds of candidate regions contributing to trotting racing ability in the horse. Likely resulting from the cumulative effects of many variants across the genome, racing ability continues to demonstrate its polygenic nature with candidate regions implicating genes influencing both musculature and neurological development.
Sections du résumé
BACKGROUND
BACKGROUND
Horses have been strongly selected for speed, strength, and endurance-exercise traits since the onset of domestication. As a result, highly specialized horse breeds have developed with many modern horse breeds often representing closed populations with high phenotypic and genetic uniformity. However, a great deal of variation still exists between breeds, making the horse particularly well suited for genetic studies of athleticism. To identify genomic regions associated with athleticism as it pertains to trotting racing ability in the horse, the current study applies a pooled sequence analysis approach using a unique Nordic horse model.
RESULTS
RESULTS
Pooled sequence data from three Nordic horse populations were used for F
CONCLUSIONS
CONCLUSIONS
Not unexpected for genomic investigations of complex traits, the current study identified hundreds of candidate regions contributing to trotting racing ability in the horse. Likely resulting from the cumulative effects of many variants across the genome, racing ability continues to demonstrate its polygenic nature with candidate regions implicating genes influencing both musculature and neurological development.
Identifiants
pubmed: 30717660
doi: 10.1186/s12864-019-5484-9
pii: 10.1186/s12864-019-5484-9
pmc: PMC6360714
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104Subventions
Organisme : Svenska Forskningsrådet Formas (SE)
ID : 2016-00947
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