Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM.

3' Untranslated Regions AU Rich Elements / genetics Crystallography, X-Ray Dimerization ELAV Proteins / chemistry ELAV-Like Protein 1 / chemistry Humans Magnetic Resonance Spectroscopy RNA Recognition Motif / genetics RNA-Binding Proteins / chemistry Ribonucleoside Diphosphate Reductase / chemistry Tumor Suppressor Proteins / chemistry
NMR spectroscopy RNA-binding protein crystal structure dimerization multiple register

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
19 02 2019
Historique:
pubmed: 6 2 2019
medline: 3 5 2019
entrez: 6 2 2019
Statut: ppublish

Résumé

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate-rich elements (AU-rich elements; AREs). These are a major class of

Identifiants

DOI: 10.1073/pnas.1808696116 PMID: 30718402 PMC: PMC6386705
pubmed: 30718402
pii: 1808696116
doi: 10.1073/pnas.1808696116
pmc: PMC6386705
doi:

Substances chimiques

3' Untranslated Regions 0
ELAV Proteins 0
ELAV-Like Protein 1 0
RNA-Binding Proteins 0
Tumor Suppressor Proteins 0
ribonucleotide reductase M2 EC 1.17.4.-
RRM1 protein, human EC 1.17.4.1
Ribonucleoside Diphosphate Reductase EC 1.17.4.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2935-2944

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Nina Ripin (N)

Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.
Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.
ORCID: 0000-0001-6099-6506

Julien Boudet (J)

Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.

Malgorzata M Duszczyk (MM)

Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland.

Alexandra Hinniger (A)

Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.

Michael Faller (M)

Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland.

Miroslav Krepl (M)

Institute of Biophysics, Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Department of Physical Chemistry, Faculty of Science, Regional Centre of Advanced Technologies and Materials, Palacky University Olomouc, 771 46 Olomouc, Czech Republic.
ORCID: 0000-0002-9833-4281

Abhilash Gadi (A)

Department of Microbiology, New York University School of Medicine, New York, NY 10016.

Robert J Schneider (RJ)

Department of Microbiology, New York University School of Medicine, New York, NY 10016.
ORCID: 0000-0001-5807-5564

Jiří Šponer (J)

Institute of Biophysics, Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Department of Physical Chemistry, Faculty of Science, Regional Centre of Advanced Technologies and Materials, Palacky University Olomouc, 771 46 Olomouc, Czech Republic.

Nicole C Meisner-Kober (NC)

Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.

Frédéric H-T Allain (FH)

Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; nina.ripin@mol.biol.ethz.ch nicole.meisner-kober@sbg.ac.at frederic.allain@mol.biol.ethz.ch.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › Molecular basis for AU-rich element...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › Éléments riches en AU › Molecular basis for AU-rich element...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Molecular basis for AU-rich element...
questionsmedicales.fr › Métabolisme › Dimérisation › Molecular basis for AU-rich element...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Antigènes Hu de l'encéphalomyélite paranéoplasique › Molecular basis for AU-rich element...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Antigènes Hu de l'encéphalomyélite paranéoplasique › Protéine-1 similaire à ELAV › Molecular basis for AU-rich element...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular basis for AU-rich element...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Molecular basis for AU-rich element...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs de liaison à l'ARN › Motif de reconnaissance de l'ARN › Molecular basis for AU-rich element...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Molecular basis for AU-rich element...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Ribonucleotide reductases › Ribonucleoside diphosphate reductase › Molecular basis for AU-rich element...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Molecular basis for AU-rich element...