Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release.
Parkinson’s disease
addiction
associative thalamus
caudate
goal-directed behavior
movement
putamen
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
06
06
2018
revised:
29
10
2018
accepted:
09
01
2019
entrez:
7
2
2019
pubmed:
7
2
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
Glutamatergic projections of the thalamic rostral intralaminar nuclei of the thalamus (rILN) innervate the dorsal striatum (DS) and are implicated in dopamine (DA)-dependent incubation of drug seeking. However, the mechanism by which rILN signaling modulates reward seeking and striatal DA release is unknown. We find that activation of rILN inputs to the DS drives cholinergic interneuron burst-firing behavior and DA D2 receptor-dependent post-burst pauses in cholinergic interneuron firing. In vivo, optogenetic activation of this pathway drives reinforcement in a DA D1 receptor-dependent manner, and chemogenetic suppression of the rILN reduces dopaminergic nigrostriatal terminal activity as measured by fiber photometry. Altogether, these data provide evidence that the rILN activates striatal cholinergic interneurons to enhance the pursuit of reward through local striatal DA release and introduce an additional level of complexity in our understanding of striatal DA signaling.
Identifiants
pubmed: 30726725
pii: S2211-1247(19)30062-2
doi: 10.1016/j.celrep.2019.01.044
pmc: PMC6402336
mid: NIHMS1520900
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1389-1398.e3Subventions
Organisme : NIDA NIH HHS
ID : F31 DA047014
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS063391
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA022340
Pays : United States
Organisme : NIAAA NIH HHS
ID : K22 AA021414
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008181
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028747
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024845
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA024683
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042595
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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