Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.
Animals
CD18 Antigens
/ deficiency
Citrobacter rodentium
/ immunology
Colitis
/ genetics
Enterobacteriaceae Infections
/ genetics
Female
Gene Expression Regulation
/ immunology
Inflammasomes
/ immunology
Interleukin-17
/ genetics
Interleukin-1beta
/ genetics
Interleukins
/ genetics
Intestines
/ immunology
Macrophages
/ immunology
Male
Membrane Glycoproteins
/ genetics
Mice
Mice, Knockout
NLR Family, Pyrin Domain-Containing 3 Protein
/ genetics
Neuropeptides
/ genetics
Neutrophil Infiltration
Neutrophils
/ immunology
Reactive Oxygen Species
/ immunology
Survival Analysis
rac1 GTP-Binding Protein
/ genetics
Interleukin-22
Citrobacter rodentium
IL-22
colitis
infection
inflammation
innate immunity
innate lymphoid cells
leukocyte adhesion deficiency
macrophages
β2-integrins
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
05
09
2018
revised:
07
12
2018
accepted:
15
01
2019
entrez:
7
2
2019
pubmed:
7
2
2019
medline:
28
3
2020
Statut:
ppublish
Résumé
β2-integrins promote neutrophil recruitment to infected tissues and are crucial for host defense. Neutrophil recruitment is defective in leukocyte adhesion deficiency type-1 (LAD1), a condition caused by mutations in the CD18 (β2-integrin) gene. Using a model of Citrobacter rodentium (CR)-induced colitis, we show that CD18
Identifiants
pubmed: 30726742
pii: S2211-1247(19)30083-X
doi: 10.1016/j.celrep.2019.01.054
pmc: PMC6404229
mid: NIHMS1520973
pii:
doi:
Substances chimiques
CD18 Antigens
0
IL1B protein, mouse
0
Il17a protein, mouse
0
Inflammasomes
0
Interleukin-17
0
Interleukin-1beta
0
Interleukins
0
Lad1 protein, mouse
0
Membrane Glycoproteins
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Neuropeptides
0
Nlrp3 protein, mouse
0
Rac1 protein, mouse
0
Reactive Oxygen Species
0
rac1 GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1614-1626.e5Subventions
Organisme : NIDCR NIH HHS
ID : R37 DE026152
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE015254
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI068730
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024716
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE024153
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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