Using the Proton Energy Spectrum and Microdosimetry to Model Proton Relative Biological Effectiveness.
Journal
International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
30
08
2018
revised:
28
12
2018
accepted:
29
01
2019
pubmed:
8
2
2019
medline:
15
11
2019
entrez:
8
2
2019
Statut:
ppublish
Résumé
We introduce a methodology to calculate the microdosimetric quantity dose-mean lineal energy for input into the microdosimetric kinetic model (MKM) to model the relative biological effectiveness (RBE) of proton irradiation experiments. The data from 7 individual proton RBE experiments were included in this study. In each experiment, the RBE at several points along the Bragg curve was measured. Monte Carlo simulations to calculate the lineal energy probability density function of 172 different proton energies were carried out with use of Geant4 DNA. We calculated the fluence-weighted lineal energy probability density function (f Both the MKM and LET Our 3 key accomplishments include the following: (1) We developed a method that uses the proton energy spectra and lineal energy distributions of those protons to calculate dose-mean lineal energy. (2) We demonstrated that our application of the MKM provides theoretical validation of proton irradiation experiments that show that RBE is significantly greater than 1.1. (3) We showed that there is no clear evidence that the MKM is better than LET
Identifiants
pubmed: 30731186
pii: S0360-3016(19)30185-3
doi: 10.1016/j.ijrobp.2019.01.094
pmc: PMC6499683
mid: NIHMS1523838
pii:
doi:
Substances chimiques
Protons
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-324Subventions
Organisme : NCI NIH HHS
ID : U19 CA021239
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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