Identification of the Regulatory Elements and Target Genes of Megakaryopoietic Transcription Factor MEF2C.
Blood Platelets
/ physiology
Bone Marrow
/ physiology
CRISPR-Cas Systems
Cell Differentiation
Cell Line
Chromatin Immunoprecipitation
Gene Expression Regulation
Gene Ontology
Humans
Induced Pluripotent Stem Cells
/ physiology
MEF2 Transcription Factors
/ genetics
Megakaryocytes
/ physiology
RNA, Small Interfering
/ genetics
Regulatory Elements, Transcriptional
/ genetics
Thrombopoiesis
/ genetics
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
pubmed:
8
2
2019
medline:
10
1
2020
entrez:
8
2
2019
Statut:
ppublish
Résumé
Megakaryopoiesis produces specialized haematopoietic stem cells in the bone marrow that give rise to megakaryocytes which ultimately produce platelets. Defects in megakaryopoiesis can result in altered platelet counts and physiology, leading to dysfunctional haemostasis and thrombosis. Additionally, dysregulated megakaryopoiesis is also associated with myeloid pathologies. Transcription factors play critical roles in cell differentiation by regulating the temporal and spatial patterns of gene expression which ultimately decide cell fate. Several transcription factors have been described as regulating megakaryopoiesis including myocyte enhancer factor 2C (MEF2C); however, the genes regulated by MEF2C that influence megakaryopoiesis have not been reported. Using chromatin immunoprecipitation-sequencing and Gene Ontology data we identified five candidate genes that are bound by MEF2C and regulate megakaryopoiesis:
Identifiants
pubmed: 30731491
doi: 10.1055/s-0039-1678694
pmc: PMC6932631
mid: NIHMS1062352
doi:
Substances chimiques
MEF2 Transcription Factors
0
RNA, Small Interfering
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
716-725Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128234
Pays : United States
Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
None declared.
Références
J Thromb Haemost. 2013 Apr;11(4):593-604
pubmed: 23311859
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10141-6
pubmed: 19497860
Stem Cell Res. 2016 Mar;16(2):338-41
pubmed: 27345999
Hum Mol Genet. 2010 Oct 15;19(R2):R137-44
pubmed: 20805105
Cell. 2016 Nov 17;167(5):1415-1429.e19
pubmed: 27863252
Mol Cell. 2018 Mar 15;69(6):1017-1027.e6
pubmed: 29526696
Blood Rev. 2017 Jan;31(1):1-10
pubmed: 27450272
Hematology Am Soc Hematol Educ Program. 2007;:363-70
pubmed: 18024652
Am J Hum Genet. 2016 Jul 7;99(1):40-55
pubmed: 27346686
Cell Res. 2011 Aug;21(8):1196-209
pubmed: 21556037
Haematologica. 2014 Aug;99(8):1292-303
pubmed: 24763403
Blood. 2009 Apr 9;113(15):3461-71
pubmed: 19211936
Nature. 2015 Feb 19;518(7539):314-6
pubmed: 25693562
Oncogene. 2014 Jan 23;33(4):403-10
pubmed: 23435431
Thromb Haemost. 2000 Mar;83(3):480-4
pubmed: 10744157
Blood. 2011 Dec 15;118(25):6544-52
pubmed: 22012064
Nature. 2011 Nov 30;480(7376):201-8
pubmed: 22139419
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
J Hematol Oncol. 2015 Oct 20;8:115
pubmed: 26487643
Cell Syst. 2016 Nov 23;3(5):491-495.e5
pubmed: 27863955
Stem Cells. 2009 May;27(5):1120-9
pubmed: 19415782
Curr Biol. 2008 Sep 9;18(17):1327-32
pubmed: 18771919
Methods Mol Biol. 2014;1185:181-94
pubmed: 25062629
Curr Biol. 2005 Dec 6;15(23):2149-55
pubmed: 16289642
Blood. 2014 Sep 25;124(13):e21-32
pubmed: 25097177
Blood. 2017 May 25;129(21):2873-2881
pubmed: 28416505
Thromb Res. 2015 Aug;136(2):361-6
pubmed: 26148565
Annu Rev Biochem. 2010;79:351-79
pubmed: 20533884
Nat Med. 2013 Dec;19(12):1609-16
pubmed: 24216752
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):238-43
pubmed: 19114653
Nat Immunol. 2009 Mar;10(3):289-96
pubmed: 19169261
Physiol Genomics. 2008 Apr 22;33(2):159-69
pubmed: 18252802
Clin Genet. 2012 Nov;82(5):499-501
pubmed: 22449245
Sci Rep. 2016 Apr 15;6:24356
pubmed: 27079678
Nature. 2006 Aug 17;442(7104):818-22
pubmed: 16862118
J Biol Chem. 2009 Oct 30;284(44):30673-83
pubmed: 19736310
J Biol Chem. 2011 Jan 7;286(1):208-15
pubmed: 21059642
Nucleic Acids Res. 2018 Jan 4;46(D1):D260-D266
pubmed: 29140473
Blood. 2009 Sep 17;114(12):2476-88
pubmed: 19584403
Epigenetics. 2014 Nov;9(11):1485-95
pubmed: 25482055
Blood. 1988 Jul;72(1):49-60
pubmed: 2455575
Blood. 2008 May 1;111(9):4532-41
pubmed: 18326819
Science. 2004 Sep 3;305(5689):1437-41
pubmed: 15284456
PLoS Biol. 2011 Apr;9(4):e1001046
pubmed: 21526222
J Thromb Haemost. 2013 Jun;11 Suppl 1:340-50
pubmed: 23809137
Am J Hum Genet. 2016 Feb 4;98(2):229-42
pubmed: 26805783
Annu Rev Cell Dev Biol. 1998;14:167-96
pubmed: 9891782
J Mol Biol. 2014 Jun 12;426(12):2283-99
pubmed: 24680668
Blood. 2007 Nov 15;110(10):3637-47
pubmed: 17664349