Ionic signalling in astroglia beyond calcium.
Astrocytes
Cl- signalling
H+ homeostasis
K+ homoeostasis
Na+ signalling
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
19
11
2018
accepted:
15
01
2019
pubmed:
9
2
2019
medline:
16
2
2021
entrez:
9
2
2019
Statut:
ppublish
Résumé
Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca
Substances chimiques
Ions
0
Sodium
9NEZ333N27
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1655-1670Informations de copyright
© 2019 The Authors. The Journal of Physiology © 2019 The Physiological Society.
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