High clustering of acute HCV infections and high rate of associated STIs among Parisian HIV-positive male patients.
Adult
Cluster Analysis
Disease Transmission, Infectious
Genotype
HIV Infections
/ complications
Hepacivirus
/ classification
Hepatitis C
/ epidemiology
Homosexuality, Male
Humans
Male
Middle Aged
Molecular Epidemiology
Paris
/ epidemiology
Phylogeny
Prevalence
Retrospective Studies
Sequence Analysis, DNA
Sexually Transmitted Diseases
/ epidemiology
HIV infection
Hepatitis C
Homosexuality
Phylogeny
Sexually transmitted infections
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
10
10
2018
revised:
16
01
2019
accepted:
02
02
2019
pubmed:
12
2
2019
medline:
9
8
2019
entrez:
12
2
2019
Statut:
ppublish
Résumé
Increasing incidence of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive men having sex with men (MSM) has been described in recent years. Phylogenetic analyses of acute HCV infections were undertaken to characterize the dynamics during the epidemic in Paris, and associated sexually transmitted infections (STIs) were evaluated. Sanger sequencing of polymerase gene was performed. Maximum likelihood phylogenies were reconstructed using FastTree 2.1 under a GTR+CAT model. Transmission chains were defined as clades with a branch probability ≥0.80 and intraclade genetic distances <0.02 nucleotide substitutions per sites. STIs detected ≤1 month before HCV diagnosis were considered. Among the 85 studied patients, at least 81.2% were MSM. Respectively, 47.6%, 39.0%, 11.0% and 2.4% were infected with genotypes 1a, 4d, 3a and 2k. At least 91.8% were co-infected with HIV. HCV re-infection was evidenced for 24.7% of patients and STIs for 20.0% of patients. Twenty-two transmission chains were identified, including 52 acute hepatitis C (11 pairs and 11 clusters from three to seven patients). These results revealed strong clustering of acute HCV infections. Thus, rapid treatment of both chronic and acute infections is needed among this population to decrease the prevalence of HCV, in combination with preventive behavioural interventions.
Sections du résumé
BACKGROUND
BACKGROUND
Increasing incidence of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-positive men having sex with men (MSM) has been described in recent years. Phylogenetic analyses of acute HCV infections were undertaken to characterize the dynamics during the epidemic in Paris, and associated sexually transmitted infections (STIs) were evaluated.
METHODS
METHODS
Sanger sequencing of polymerase gene was performed. Maximum likelihood phylogenies were reconstructed using FastTree 2.1 under a GTR+CAT model. Transmission chains were defined as clades with a branch probability ≥0.80 and intraclade genetic distances <0.02 nucleotide substitutions per sites. STIs detected ≤1 month before HCV diagnosis were considered.
RESULTS
RESULTS
Among the 85 studied patients, at least 81.2% were MSM. Respectively, 47.6%, 39.0%, 11.0% and 2.4% were infected with genotypes 1a, 4d, 3a and 2k. At least 91.8% were co-infected with HIV. HCV re-infection was evidenced for 24.7% of patients and STIs for 20.0% of patients. Twenty-two transmission chains were identified, including 52 acute hepatitis C (11 pairs and 11 clusters from three to seven patients).
CONCLUSIONS
CONCLUSIONS
These results revealed strong clustering of acute HCV infections. Thus, rapid treatment of both chronic and acute infections is needed among this population to decrease the prevalence of HCV, in combination with preventive behavioural interventions.
Identifiants
pubmed: 30742957
pii: S0924-8579(19)30025-1
doi: 10.1016/j.ijantimicag.2019.02.002
pii:
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Pagination
678-681Informations de copyright
Copyright © 2019. Published by Elsevier B.V.