Argon reduces the pulmonary vascular tone in rats and humans by GABA-receptor activation.

Animals Argon / pharmacology Baclofen / pharmacology Blood Pressure / drug effects Edema / chemically induced Endothelin-1 / pharmacology Female GABA-B Receptor Agonists / pharmacology Hemodynamics / drug effects Humans Lung / pathology Muscle Contraction / drug effects Pulmonary Artery / drug effects Rats Rats, Wistar Receptors, GABA-B / chemistry

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 02 2019
Historique:
received: 12 09 2018
accepted: 21 12 2018
entrez: 15 2 2019
pubmed: 15 2 2019
medline: 26 8 2020
Statut: epublish

Résumé

Argon exerts neuroprotection. Thus, it might improve patients' neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (P

Identifiants

DOI: 10.1038/s41598-018-38267-y PMID: 30760775 PMC: PMC6374423
pubmed: 30760775
doi: 10.1038/s41598-018-38267-y
pii: 10.1038/s41598-018-38267-y
pmc: PMC6374423
doi:

Substances chimiques

Endothelin-1 0
GABA-B Receptor Agonists 0
Receptors, GABA-B 0
Argon 67XQY1V3KH
Baclofen H789N3FKE8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1902

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Auteurs

Said Suleiman (S)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Sergej Klassen (S)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Ira Katz (I)

Medical Research & Development, Air Liquide Santé Internationale, Centre de Recherche Paris-Saclay, 78354, Jouy-en-Josas, France.

Galina Balakirski (G)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Julia Krabbe (J)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
ORCID: 0000-0003-4205-9783

Saskia von Stillfried (S)

Institute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Svetlana Kintsler (S)

Institute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Till Braunschweig (T)

Institute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Aaron Babendreyer (A)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Jan Spillner (J)

Department of Cardiac and Thoracic Surgery, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Sebastian Kalverkamp (S)

Department of Cardiac and Thoracic Surgery, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Thomas Schröder (T)

Department of Surgery, Luisenhospital Aachen, 52064, Aachen, Germany.

Manfred Moeller (M)

Institute for Occupational, Social and Environmental Medicine, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Mark Coburn (M)

Department of Anaesthesiology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.

Stefan Uhlig (S)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Christian Martin (C)

Institute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.

Annette D Rieg (AD)

Department of Anaesthesiology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany. arieg@ukaachen.de.
ORCID: 0000-0002-7043-5494

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Gaz rares › Argon › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Baclofène › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Oedème › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Endothélines › Endothéline-1 › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Agonistes GABA › Agonistes du recepteur GABA-B › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Appareil respiratoire › Poumon › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artère pulmonaire › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Argon reduces the pulmonary vascular tone in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › Argon reduces the pulmonary vascular tone in...