Differential expression of neurexin genes in the mouse brain.
RRID AB_514500
RRID AB_840257
RRIDs: RRID SCR_003070
brain
in situ hybridization
mice
neurexin
synapse
trans-synaptic adhesion
Journal
The Journal of comparative neurology
ISSN: 1096-9861
Titre abrégé: J Comp Neurol
Pays: United States
ID NLM: 0406041
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
14
09
2018
revised:
04
01
2019
accepted:
01
02
2019
pubmed:
15
2
2019
medline:
15
9
2020
entrez:
15
2
2019
Statut:
ppublish
Résumé
Synapses, highly specialized membrane junctions between neurons, connect presynaptic neurotransmitter release sites and postsynaptic ligand-gated channels. Neurexins (Nrxns), a family of presynaptic adhesion molecules, have been characterized as major regulators of synapse development and function. Via their extracellular domains, Nrxns bind to different postsynaptic proteins, generating highly diverse functional readouts through their postsynaptic binding partners. Not surprisingly given these versatile protein interactions, mutations and deletions of Nrxn genes have been identified in patients with autism spectrum disorders, intellectual disabilities, and schizophrenia. Therefore, elucidating the expression profiles of Nrxns in the brain is of high significance. Here, using chromogenic and fluorescent in situ hybridization, we characterize the expression patterns of Nrxn isoforms throughout the brain. We found that each Nrxn isoform displays a unique expression profile in a region-, cell type-, and sensory system-specific manner. Interestingly, we also found that αNrxn1 and αNrxn2 mRNAs are expressed in non-neuronal cells, including astrocytes and oligodendrocytes. Lastly, we found diverse expression patterns of genes that encode Nrxn binding proteins, such as Neuroligins (Nlgns), Leucine-rich repeat transmembrane neuronal protein (Lrrtms) and Latrophilins (Adgrls), suggesting that Nrxn proteins can mediate numerous combinations of trans-synaptic interactions. Together, our anatomical profiling of Nrxn gene expression reflects the diverse roles of Nrxn molecules.
Identifiants
pubmed: 30761534
doi: 10.1002/cne.24664
pmc: PMC6592846
mid: NIHMS1521319
doi:
Substances chimiques
Neural Cell Adhesion Molecules
0
Protein Isoforms
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1940-1965Subventions
Organisme : NINDS NIH HHS
ID : R01 NS085215
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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