Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation.

Amygdala / diagnostic imaging Animals Brain / diagnostic imaging Brain Mapping Functional Neuroimaging Gyrus Cinguli / diagnostic imaging Macaca Magnetic Resonance Imaging Neural Pathways / physiology Ultrasonic Waves
amygdala cingulate cortex functional connectivity limbic macaque monkey neuromodulation resting-state connectivity transcranial stimulation ultrasound

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
20 03 2019
Historique:
received: 18 07 2018
revised: 29 11 2018
accepted: 14 01 2019
pubmed: 16 2 2019
medline: 5 11 2019
entrez: 16 2 2019
Statut: ppublish

Résumé

The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds.

Identifiants

DOI: 10.1016/j.neuron.2019.01.019 PMID: 30765166 PMC: PMC6520498
pubmed: 30765166
pii: S0896-6273(19)30046-7
doi: 10.1016/j.neuron.2019.01.019
pmc: PMC6520498
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1109-1116.e5

Subventions

Organisme : Medical Research Council
ID : MR/P024955/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0902373
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600994
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Davide Folloni (D)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: davide.folloni@psy.ox.ac.uk.

Lennart Verhagen (L)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: lennart.verhagen@psy.ox.ac.uk.

Rogier B Mars (RB)

Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 HR Nijmegen, the Netherlands.

Elsa Fouragnan (E)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; School of Psychology, University of Plymouth, Plymouth PL4 8AA, UK.

Charlotte Constans (C)

Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Univ Paris Diderot, Sorbonne Paris Cité, Paris 75012, France.

Jean-François Aubry (JF)

Physics for Medicine Paris, Inserm, ESPCI Paris, CNRS, PSL Research University, Paris 75012, France.

Matthew F S Rushworth (MFS)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

Jérôme Sallet (J)

Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford OX1 3SR, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. Electronic address: jerome.sallet@psy.ox.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Amygdale (système limbique) › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe limbique › Gyrus du cingulum › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Manipulation of Subcortical and Deep Cortical...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Son (physique) › Ondes ultrasonores › Manipulation of Subcortical and Deep Cortical...