Parallel adaptation of rabbit populations to myxoma virus.
Adaptation, Biological
/ genetics
Alleles
Animals
Australia
Evolution, Molecular
France
Gene Frequency
Genetic Variation
Immunity, Innate
/ genetics
Interferon alpha-2
/ genetics
Myxoma virus
/ immunology
Myxomatosis, Infectious
/ genetics
Polymorphism, Single Nucleotide
Population
Rabbits
/ genetics
United Kingdom
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
22 03 2019
22 03 2019
Historique:
received:
13
07
2018
revised:
10
12
2018
accepted:
01
02
2019
pubmed:
16
2
2019
medline:
24
8
2019
entrez:
16
2
2019
Statut:
ppublish
Résumé
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein's antiviral effect.
Identifiants
pubmed: 30765607
pii: science.aau7285
doi: 10.1126/science.aau7285
pmc: PMC6433279
mid: EMS81826
doi:
Substances chimiques
Interferon alpha-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
1319-1326Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : European Research Council
ID : 281668
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI080607
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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