Regions of homozygosity as risk factors for multiple myeloma.
genetics
multiple myeloma
risk factor
Journal
Annals of human genetics
ISSN: 1469-1809
Titre abrégé: Ann Hum Genet
Pays: England
ID NLM: 0416661
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
18
05
2018
revised:
30
11
2018
accepted:
31
01
2019
pubmed:
16
2
2019
medline:
6
5
2020
entrez:
16
2
2019
Statut:
ppublish
Résumé
Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly different. However, one ROH at chromosome 9q21, harboring the B-cell transcription factor gene KLF9, showed evidence of a consistent association and may therefore warrant further investigation as a candidate risk factor for MM. Overall, our analysis provides little support for a homozygosity signature being a significant factor in MM risk.
Identifiants
pubmed: 30768683
doi: 10.1111/ahg.12304
pmc: PMC6563058
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-238Subventions
Organisme : Medical Research Council
ID : G1001799
Pays : United Kingdom
Organisme : Blood Cancer UK
Pays : United Kingdom
Organisme : Myeloma UK
Pays : International
Organisme : Cancer Research UK
ID : C1298/A8362
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Annals of Human Genetics published by University College London (UCL) and John Wiley & Sons Ltd.
Références
Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13420-5
pubmed: 17673551
Behav Genet. 2013 Nov;43(6):455-67
pubmed: 23978897
Ann Hum Genet. 2019 Jul;83(4):231-238
pubmed: 30768683
PLoS Biol. 2006 Mar;4(3):e72
pubmed: 16494531
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Lancet. 2010 Dec 11;376(9757):1989-99
pubmed: 21131037
J Biomed Res. 2013 May;27(3):208-14
pubmed: 23720676
Nat Rev Genet. 2018 Apr;19(4):220-234
pubmed: 29335644
JAMA Neurol. 2015 Nov;72(11):1313-23
pubmed: 26366463
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Sci Rep. 2015 Jul 24;5:12473
pubmed: 26208354
Blood. 2012 Feb 9;119(6):1450-8
pubmed: 22144178
PLoS One. 2012;7(4):e34840
pubmed: 22536334
PLoS One. 2015 Mar 03;10(3):e0118935
pubmed: 25734509
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19942-7
pubmed: 18077426
Nature. 2010 Oct 28;467(7319):1061-73
pubmed: 20981092
Int J Hematol. 2016 Sep;104(3):273-80
pubmed: 27169614
PLoS One. 2012;7(3):e28787
pubmed: 22427796
Nat Rev Genet. 2009 Sep;10(9):639-50
pubmed: 19687804
Nat Genet. 2013 Oct;45(10):1221-1225
pubmed: 23955597
Eur J Cancer. 2006 Jul;42(11):1661-70
pubmed: 16753294
PLoS Genet. 2017 Jul 17;13(7):e1006916
pubmed: 28715421
Nat Genet. 2011 Nov 27;44(1):58-61
pubmed: 22120009
JAMA. 2008 Mar 26;299(12):1437-45
pubmed: 18364486
Cancer. 1976 Dec;38(6):2548-50
pubmed: 1069604
J Immunol. 2010 Dec 15;185(12):7527-36
pubmed: 21059893
Hum Genet. 2011 Jan;129(1):1-15
pubmed: 21104274
Nat Commun. 2016 Jul 01;7:12050
pubmed: 27363682
N Engl J Med. 2011 Mar 17;364(11):1046-60
pubmed: 21410373
Nat Commun. 2015 May 26;6:7213
pubmed: 26007630
Nature. 2009 Oct 8;461(7265):747-53
pubmed: 19812666
Genetics. 1989 Nov;123(3):585-95
pubmed: 2513255
Nat Commun. 2018 Sep 13;9(1):3707
pubmed: 30213928
PLoS One. 2016 Apr 28;11(4):e0154259
pubmed: 27123581
Nucleic Acids Res. 2014 Jan;42(Database issue):D910-6
pubmed: 24194603
BMC Cancer. 2016 Mar 16;16:227
pubmed: 26984635