Bacterial Adhesion on Soft Materials: Passive Physicochemical Interactions or Active Bacterial Mechanosensing?
bacterial adhesion
mechanical stiffness
polydimethylsiloxane
polystyrene beads
surface colonization
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
18
10
2018
revised:
27
01
2019
pubmed:
19
2
2019
medline:
23
6
2020
entrez:
19
2
2019
Statut:
ppublish
Résumé
The influence of mechanical stiffness of biomaterials on bacterial adhesion is only sparsely studied and the mechanism behind this influence remains unclear. Here, bacterial adhesion on polydimethylsiloxane (PDMS) samples, having four different degrees of stiffness with Young's modulus ranging from 0.06 to 4.52 MPa, is investigated. Escherichia coli and Pseudomonas aeruginosa are found to adhere in greater numbers on soft PDMS (7- and 27-fold increase, respectively) than on stiff PDMS, whereas Staphylococcus aureus adheres in similar numbers on the four tested surfaces. To determine whether the observed adhesion behavior is caused by bacteria-specific mechanisms, abiotic polystyrene (PS) beads are employed as bacteria substitutes. Carboxylate-modified PS (PS-COOH) beads exhibit the same adhesion pattern as E. coli and P. aeruginosa with four times more adhered beads on soft PDMS than on stiff PDMS. In contrast, amine-modified PS (PS-NH
Identifiants
pubmed: 30773835
doi: 10.1002/adhm.201801323
doi:
Substances chimiques
Dimethylpolysiloxanes
0
Polystyrenes
0
baysilon
63148-62-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1801323Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.