Structural Insights into Peptides Bound to the Surface of Silica Nanopores.
biomineralization
dynamic nuclear polarization
hybrid materials
mesoporous silica
solid-phase peptide synthesis
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
01
11
2018
pubmed:
19
2
2019
medline:
24
4
2019
entrez:
19
2
2019
Statut:
ppublish
Résumé
The structure and surface functionalization of biologically relevant silica-based hybrid materials was investigated by 2D solid-state NMR techniques combined with dynamic nuclear polarization (DNP). This approach was applied to a model system of mesoporous silica, which was modified through in-pore grafting of small peptides by solid-phase peptide synthesis (SPPS). To prove the covalent binding of the peptides on the surface, DNP-enhanced solid-state NMR was used for the detection of
Identifiants
pubmed: 30775810
doi: 10.1002/chem.201805480
doi:
Substances chimiques
Dipeptides
0
Propylamines
0
Silanes
0
glycylphenylalanine
721-66-4
Silicon Dioxide
7631-86-9
amino-propyl-triethoxysilane
L8S6UBW552
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5214-5221Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : Forschergruppe FOR 1583 grant Bu-911/18-1/2
Organisme : Hessisches Ministerium für Wissenschaft und Kunst
ID : LOEWE iNAPO
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.