Cell shape and substrate stiffness drive actin-based cell polarity.
Journal
Physical review. E
ISSN: 2470-0053
Titre abrégé: Phys Rev E
Pays: United States
ID NLM: 101676019
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
03
03
2018
entrez:
21
2
2019
pubmed:
20
2
2019
medline:
5
3
2019
Statut:
ppublish
Résumé
A general trait of living cells is their ability to exert contractile stresses on their surroundings and thus respond to substrate rigidity. At the cellular scale, this response affects cell shape, polarity, and ultimately migration. The regulation of cell shape together with rigidity sensing remains largely unknown. In this article we show that both substrate rigidity and cell shape contribute to drive actin organization and cell polarity. Increasing substrate rigidity affects bulk properties of the actin cytoskeleton by favoring long-lived actin stress fibers with increased nematic interactions, whereas cell shape imposes a local alignment of actin fibers at the cell periphery.
Identifiants
pubmed: 30780372
doi: 10.1103/PhysRevE.99.012412
pmc: PMC6464093
mid: EMS82551
doi:
Substances chimiques
Actins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
012412Subventions
Organisme : European Research Council
ID : 617233
Pays : International
Références
Nano Lett. 2017 Jan 11;17(1):399-406
pubmed: 27990827
Curr Opin Cell Biol. 2014 Oct;30:68-73
pubmed: 24998185
Nat Cell Biol. 2001 May;3(5):466-72
pubmed: 11331874
Nat Commun. 2015 Jun 25;6:7525
pubmed: 26109233
Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):975-8
pubmed: 15653772
Nat Cell Biol. 2015 Aug;17(8):955-63
pubmed: 26121555
Nat Methods. 2010 Dec;7(12):969-71
pubmed: 21076420
Biomaterials. 2002 Jul;23(14):2945-54
pubmed: 12069336
J Cell Sci. 2012 Apr 15;125(Pt 8):1855-64
pubmed: 22544950
Nature. 1991 Jul 11;352(6331):126-31
pubmed: 2067574
Methods Cell Biol. 2015;125:289-308
pubmed: 25640435
Biophys J. 2012 Aug 22;103(4):640-8
pubmed: 22947925
Nat Cell Biol. 2016 May;18(5):540-8
pubmed: 27065098
Nat Cell Biol. 2011 Nov 13;13(12):1457-65
pubmed: 22081092
Dev Cell. 2006 May;10(5):673-80
pubmed: 16678780
Trends Cell Biol. 2016 Jun;26(6):420-433
pubmed: 26920934
Cell. 2013 May 23;153(5):948-62
pubmed: 23706734
Nature. 2001 Feb 1;409(6820):630-3
pubmed: 11214323
Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19771-6
pubmed: 17179050
J Cell Sci. 2017 Apr 1;130(7):1201-1207
pubmed: 28365593
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1999 Jul;60(1):628-37
pubmed: 11969803
Dev Cell. 2002 Feb;2(2):153-8
pubmed: 11832241
Proc Natl Acad Sci U S A. 2012 May 1;109(18):6933-8
pubmed: 22509005
Cell. 2006 Jun 30;125(7):1361-74
pubmed: 16814721