In vitro activity of diphenyl diselenide and ebselen alone and in combination with antifungal agents against Trichosporon asahii.
fluconazole resistance
interactions
microdilution
organoselenium compounds
susceptibility
Journal
Mycoses
ISSN: 1439-0507
Titre abrégé: Mycoses
Pays: Germany
ID NLM: 8805008
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
28
09
2018
revised:
13
01
2019
accepted:
13
02
2019
pubmed:
21
2
2019
medline:
21
5
2019
entrez:
21
2
2019
Statut:
ppublish
Résumé
This study evaluated the in vitro susceptibility of Trichosporon asahii strains to diphenyl diselenide (DPDS) and ebselen (EBS) alone and in combination with amphotericin B (AMB), fluconazole (FCZ), itraconazole (ITZ) and caspofungin (CAS) using the microdilution method. EBS showed in vitro activity against T asahii strains with minimal inhibitory concentration (MIC) ranged from 0.25 to 8.0 μg/mL. For DPDS, the MIC ranged from 8.0 to 64 μg/mL. The combinations demonstrating the greatest synergism rate against fluconazole-resistant T asahii strains were the following: CAS + DPDS (96.67%), AMB + DPDS (93.33%), FCZ + DPDS (86.67%) and ITZ + DPDS (83.33%). The combinations AMB + DPDS and AMB + EBS exhibited the highest synergism rate against the fluconazole-susceptible (FS) T asahii strains (90%). Antagonism was observed in the following combinations: FCZ + EBS (80%) and FCZ + DPDS (13.33%) against the FS strains, and ITZ + EBS (20%) against the FR strains. Our findings suggest that the antimicrobial activity of DPDS and EBS against T. asahii and its use as an adjuvant therapy with antifungal agents warrant in vivo experimental investigation.
Substances chimiques
Antifungal Agents
0
Azoles
0
Benzene Derivatives
0
Isoindoles
0
Organoselenium Compounds
0
diphenyldiselenide
1666-13-3
ebselen
40X2P7DPGH
Banques de données
GENBANK
['KR233249', 'KT438844', 'KR872655', 'KR872656', 'KR872657', 'KR872660', 'KR872661', 'KR233246', 'KR233247', 'KR233248', 'KT365854', 'KT365855', 'KR872662', 'KT438839', 'KT438840', 'KR872663', 'KR912056', 'KT438842', 'KT365856', 'KT438847', 'KR912058', 'KR912064', 'KT365858', 'KR912065', 'KT365859', 'KT438846', 'KT365860', 'KR912059', 'KT365861', 'KR912066']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
428-433Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 304168/2012-2
Informations de copyright
© 2019 Blackwell Verlag GmbH.