Quantitative CT-derived vessel metrics in idiopathic pulmonary fibrosis: A structure-function study.
Adult
Aged
Aged, 80 and over
Algorithms
Carbon Monoxide
Female
Humans
Idiopathic Pulmonary Fibrosis
/ diagnostic imaging
Male
Middle Aged
Pulmonary Artery
/ diagnostic imaging
Pulmonary Diffusing Capacity
Radiographic Image Interpretation, Computer-Assisted
Severity of Illness Index
Tidal Volume
Tomography, X-Ray Computed
/ methods
Vital Capacity
interstitial lung disease
lung fibrosis
radiology and other imaging
respiratory structure and function
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
03
09
2018
accepted:
09
01
2019
pubmed:
21
2
2019
medline:
18
4
2020
entrez:
21
2
2019
Statut:
ppublish
Résumé
This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF). A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Results were evaluated against readouts from lung function tests. Normalized vessel volume expressed as a percentage of total lung volume was moderately correlated with functional indices on univariable linear regression analysis: forced vital capacity (R Our study confirms previous observations of links between vessel volume and functional measures of disease severity in IPF using a new vessel quantitation tool. Additionally, the new tool shows independent linkages of normalized vessel volume and vessel heterogeneity with functional indices. Quantitative vessel metrics do not appear to reflect vasculopathic damage in IPF.
Sections du résumé
BACKGROUND AND OBJECTIVE
This study aimed to investigate whether quantitative lung vessel morphology determined by a new fully automated algorithm is associated with functional indices in idiopathic pulmonary fibrosis (IPF).
METHODS
A total of 152 IPF patients had vessel volume, density, tortuosity and heterogeneity quantified from computed tomography (CT) images by a fully automated algorithm. Separate quantitation of vessel metrics in pulmonary arteries and veins was performed in 106 patients. Results were evaluated against readouts from lung function tests.
RESULTS
Normalized vessel volume expressed as a percentage of total lung volume was moderately correlated with functional indices on univariable linear regression analysis: forced vital capacity (R
CONCLUSION
Our study confirms previous observations of links between vessel volume and functional measures of disease severity in IPF using a new vessel quantitation tool. Additionally, the new tool shows independent linkages of normalized vessel volume and vessel heterogeneity with functional indices. Quantitative vessel metrics do not appear to reflect vasculopathic damage in IPF.
Identifiants
pubmed: 30786325
doi: 10.1111/resp.13485
pmc: PMC6519024
doi:
Substances chimiques
Carbon Monoxide
7U1EE4V452
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
445-452Subventions
Organisme : Wellcome Trust
ID : 209553/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2019 The Authors Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.
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