The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Animals Cell Movement Cells, Cultured Centrosome / metabolism DNA-Binding Proteins / metabolism Epithelial Cells / metabolism Epithelial-Mesenchymal Transition Humans Intercellular Junctions / metabolism Interphase Lateral Ventricles / anatomy & histology Mammary Glands, Animal / cytology Mice Microtubules / metabolism Neurogenesis Nuclear Proteins / metabolism Organ Size Organoids / cytology Transcription Factors / metabolism

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
03 2019

Historique:

received: 04 01 2018

accepted: 23 01 2019

pubmed: 23 2 2019

medline: 6 8 2019

entrez: 22 2 2019

Statut: ppublish

Résumé

The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors

Identifiants

DOI: 10.1038/s41586-019-0962-4 PMID: 30787442

pubmed: 30787442

doi: 10.1038/s41586-019-0962-4

pii: 10.1038/s41586-019-0962-4

doi:

Substances chimiques

AKNA protein, human 0

DNA-Binding Proteins 0

Nuclear Proteins 0

Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

113-117

Subventions

Organisme : NIDA NIH HHS

ID : R01 DA024681

Pays : United States

Organisme : NINDS NIH HHS

ID : R01 NS085004

Pays : United States

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