NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.
Animals
Brain
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Disease Models, Animal
Disease Progression
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Histocompatibility Antigens Class I
/ immunology
Membrane Proteins
/ immunology
Mice, Inbred C57BL
Mice, Knockout
Multiple Sclerosis
/ immunology
NK Cell Lectin-Like Receptor Subfamily K
/ genetics
Spinal Cord
/ immunology
NK cell lectin-like receptor subfamily
T lymphocytes
autoimmune disease
central nervous system
neuroinflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
10
2018
accepted:
17
01
2019
entrez:
22
2
2019
pubmed:
23
2
2019
medline:
7
1
2020
Statut:
epublish
Résumé
NKG2D is an activating receptor expressed on the surface of immune cells including subsets of T lymphocytes. NKG2D binds multiple ligands (NKG2DL) whose expression are differentially triggered in a cell type and stress specific manner. The NKG2D-NKG2DL interaction has been involved in autoimmune disorders but its role in animal models of multiple sclerosis (MS) remains incompletely resolved. Here we show that NKG2D and its ligand MULT1 contribute to the pathobiology of experimental autoimmune encephalomyelitis (EAE). MULT1 protein levels are increased in the central nervous system (CNS) at EAE disease peak; soluble MULT1 is elevated in the cerebrospinal fluid of both active and passive EAE. We establish that such soluble MULT1 enhances effector functions (e.g., IFNγ production) of activated CD8 T lymphocytes from wild type but not from NKG2D-deficient (
Identifiants
pubmed: 30787931
doi: 10.3389/fimmu.2019.00154
pmc: PMC6372829
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Klrk1 protein, mouse
0
Membrane Proteins
0
NK Cell Lectin-Like Receptor Subfamily K
0
UL16 binding protein 1, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
154Références
Brain. 2018 Jul 1;141(7):2066-2082
pubmed: 29873694
Front Immunol. 2018 Apr 23;9:827
pubmed: 29740438
Front Immunol. 2018 Jun 15;9:1282
pubmed: 29963042
Trends Neurosci. 2002 Jun;25(6):313-9
pubmed: 12086750
Science. 2015 Apr 3;348(6230):136-9
pubmed: 25745066
Clin Immunol. 2013 Dec;149(3):432-9
pubmed: 24211717
Br J Pharmacol. 2011 Oct;164(4):1079-106
pubmed: 21371012
FASEB J. 2005 Oct;19(12):1668-70
pubmed: 16081501
Hum Mol Genet. 2017 Jul 1;26(13):2565-2576
pubmed: 28379387
Neuron. 2018 Feb 21;97(4):742-768
pubmed: 29470968
Eur J Immunol. 2002 Mar;32(3):597-605
pubmed: 11857333
J Immunol. 2007 Oct 1;179(7):4503-12
pubmed: 17878346
Curr Opin Immunol. 2018 Apr;51:55-61
pubmed: 29525346
Glia. 2011 May;59(5):841-56
pubmed: 21360758
J Exp Med. 2002 Apr 1;195(7):801-10
pubmed: 11927625
Open J Immunol. 2017 Mar;7(1):1-17
pubmed: 28944101
Hum Immunol. 2008 Apr-May;69(4-5):235-40
pubmed: 18486757
J Neuroimmune Pharmacol. 2015 Dec;10(4):528-46
pubmed: 25946987
Immunol Rev. 2017 Nov;280(1):93-101
pubmed: 29027233
Brain Behav Immun. 2016 Nov;58:209-217
pubmed: 27444966
PLoS One. 2013 Nov 25;8(11):e81455
pubmed: 24282598
J Neuroimmunol. 2003 Apr;137(1-2):197-209
pubmed: 12667664
Brain. 2009 May;132(Pt 5):1175-89
pubmed: 19339255
Methods Mol Biol. 2015;1295:381-91
pubmed: 25820735
J Neurosci Res. 2018 Jun;96(6):1021-1042
pubmed: 29446144
J Neurosci Methods. 2015 May 30;247:23-31
pubmed: 25819540
J Neurosci. 2007 Jan 31;27(5):1220-8
pubmed: 17267578
Annu Rev Immunol. 2013;31:413-41
pubmed: 23298206
Eur J Immunol. 2011 Jan;41(1):47-59
pubmed: 21182076
Gut. 2017 Nov;66(11):1918-1925
pubmed: 27489241
Brain. 2007 Nov;130(Pt 11):2789-99
pubmed: 17890278
J Exp Med. 2003 May 19;197(10):1245-53
pubmed: 12756263
Trends Immunol. 2004 Mar;25(3):132-7
pubmed: 15036040
J Immunol. 2002 Oct 15;169(8):4079-83
pubmed: 12370332
J Neurol Sci. 2007 Aug 15;259(1-2):79-84
pubmed: 17382965
Front Immunol. 2018 Mar 12;9:476
pubmed: 29662484
J Immunol. 1998 Oct 1;161(7):3501-9
pubmed: 9759870
J Exp Med. 2009 Apr 13;206(4):793-805
pubmed: 19289577
Cell Res. 2015 Jun;25(6):651-2
pubmed: 25849247
Immunol Rev. 2015 Sep;267(1):88-116
pubmed: 26284473
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21647-52
pubmed: 21098276
Cancer Immunol Res. 2015 Jun;3(6):575-82
pubmed: 26041808