Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016.
Amino Acid Sequence
Animals
Disease Outbreaks
Genotype
Hemagglutinin Glycoproteins, Influenza Virus
/ genetics
Humans
Indonesia
/ epidemiology
Influenza A Virus, H5N1 Subtype
/ classification
Influenza in Birds
/ epidemiology
Phylogeny
Poultry
Poultry Diseases
/ epidemiology
Public Health Surveillance
Reassortant Viruses
/ classification
Sequence Analysis, DNA
HPAI
Indonesia
West Java
highly pathogenic avian influenza
influenza
phylogenetic analysis
reassortment
respiratory infections
viruses
Journal
Emerging infectious diseases
ISSN: 1080-6059
Titre abrégé: Emerg Infect Dis
Pays: United States
ID NLM: 9508155
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
entrez:
22
2
2019
pubmed:
23
2
2019
medline:
16
8
2019
Statut:
ppublish
Résumé
Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
Identifiants
pubmed: 30789142
doi: 10.3201/eid2503.180167
pmc: PMC6390736
doi:
Substances chimiques
Hemagglutinin Glycoproteins, Influenza Virus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
465-472Références
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