Efficient Bioconversion of Sucrose to High-Value-Added Glucaric Acid by In Vitro Metabolic Engineering.

Biotransformation Escherichia coli / enzymology Glucaric Acid / metabolism Metabolic Engineering / methods Sucrose / metabolism
biosynthesis cascade enzymes glucaric acid sucrose

Journal

ChemSusChem
ISSN: 1864-564X
Titre abrégé: ChemSusChem
Pays: Germany
ID NLM: 101319536

Informations de publication

Date de publication:
21 May 2019
Historique:
received: 19 01 2019
revised: 20 02 2019
pubmed: 23 2 2019
medline: 27 6 2019
entrez: 22 2 2019
Statut: ppublish

Résumé

Glucaric acid (GA) is a major value-added chemicals feedstock and additive, especially in the food, cosmetics, and pharmaceutical industries. The increasing demand for GA is driving the search for a more efficient and less costly production pathway. In this study, a new in vitro multi-enzyme cascade system was developed, which converts sucrose efficiently to GA in a single vessel. The in vitro system, which does not require adenosine triphosphate (ATP) or nicotinamide adenine dinucleotide (NAD

Identifiants

DOI: 10.1002/cssc.201900185 PMID: 30791217
pubmed: 30791217
doi: 10.1002/cssc.201900185
doi:

Substances chimiques

Sucrose 57-50-1
Glucaric Acid QLZ991V4A2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2278-2285

Subventions

Organisme : National Natural Science Foundation of China
ID : 1676104
Organisme : National Natural Science Foundation of China
ID : 21878105
Organisme : the National Key Research and Development Program of China
ID : 2018YFC1603403

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Hui-Hui Su (HH)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Ze-Wang Guo (ZW)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Xiao-Ling Wu (XL)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Pei Xu (P)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Ning Li (N)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Min-Hua Zong (MH)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

Wen-Yong Lou (WY)

Laboratory of Applied Biocatalysis, School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Efficient Bioconversion of Sucrose to...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Efficient Bioconversion of Sucrose to...
questionsmedicales.fr › Glucides › Oses acides › Acide D-glucarique › Efficient Bioconversion of Sucrose to...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Efficient Bioconversion of Sucrose to...
questionsmedicales.fr › Glucides › Sucres › Diholoside › Saccharose › Efficient Bioconversion of Sucrose to...