Individual- versus group-optimality in the production of secreted bacterial compounds.
Bacteria
division of labor
economy of scales
group level selection
optimal production
siderophores
Journal
Evolution; international journal of organic evolution
ISSN: 1558-5646
Titre abrégé: Evolution
Pays: United States
ID NLM: 0373224
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
02
12
2016
accepted:
01
02
2019
pubmed:
23
2
2019
medline:
10
6
2020
entrez:
23
2
2019
Statut:
ppublish
Résumé
How unicellular organisms optimize the production of compounds is a fundamental biological question. While it is typically thought that production is optimized at the individual-cell level, secreted compounds could also allow for optimization at the group level, leading to a division of labor where a subset of cells produces and shares the compound with everyone. Using mathematical modeling, we show that the evolution of such division of labor depends on the cost function of compound production. Specifically, for any trait with saturating benefits, linear costs promote the evolution of uniform production levels across cells. Conversely, production costs that diminish with higher output levels favor the evolution of specialization-especially when compound shareability is high. When experimentally testing these predictions with pyoverdine, a secreted iron-scavenging compound produced by Pseudomonas aeruginosa, we found linear costs and, consistent with our model, detected uniform pyoverdine production levels across cells. We conclude that for shared compounds with saturating benefits, the evolution of division of labor is facilitated by a diminishing cost function. More generally, we note that shifts in the level of selection from individuals to groups do not solely require cooperation, but critically depend on mechanistic factors, including the distribution of compound synthesis costs.
Identifiants
pubmed: 30793292
doi: 10.1111/evo.13701
pmc: PMC6467250
mid: EMS82614
doi:
Substances chimiques
Oligopeptides
0
Siderophores
0
pyoverdin
8062-00-8
Banques de données
Dryad
['10.5061/dryad.4r34m7b']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
675-688Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : PP00P3-139164
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : PP2EZP3-162260
Pays : International
Organisme : H2020 European Research Council
ID : 681295
Pays : International
Informations de copyright
© 2019 The Author(s). Evolution © 2019 The Society for the Study of Evolution.
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