Bioactive 3,8-Epoxy Iridoids from Valeriana jatamansi.
Animals
Cell Proliferation
/ drug effects
Circular Dichroism
Drug Resistance, Neoplasm
/ drug effects
Hep G2 Cells
Humans
Iridoids
/ chemistry
Lipopolysaccharides
/ toxicity
Macrophages
/ cytology
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Nitric Oxide
/ metabolism
Plant Roots
/ chemistry
RAW 264.7 Cells
Structure-Activity Relationship
Valerian
/ chemistry
3,8-epoxy iridoids
Valeriana jatamansi
cytotoxicity
inhibition of NO production
phytochemistry
Journal
Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
17
09
2018
accepted:
18
02
2019
pubmed:
26
2
2019
medline:
1
6
2019
entrez:
26
2
2019
Statut:
ppublish
Résumé
Twelve 3,8-epoxy iridoids, including four new compounds, jatamanins R-U (1-4), and eight known compounds (5-12), were obtained from the roots and rhizomes of Valeriana jatamansi. The structures were elucidated from analysis of spectroscopic data. The absolute configurations of 1-4 were determined by comparison of experimental and literature ECD spectra. Moreover, the compounds were evaluated for cytotoxic effects against glioma stem cells, inhibition of NO production, activity against influenza A virus and reversal of multidrug resistance of HepG2/ADR cells. Compounds 9 and 12 showed significant cytotoxic potency against GSC-18# (IC
Identifiants
pubmed: 30801931
doi: 10.1002/cbdv.201800474
doi:
Substances chimiques
Iridoids
0
Lipopolysaccharides
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1800474Subventions
Organisme : National Natural Science Foundation of China
ID : 31560103
Organisme : National Natural Science Foundation of China
ID : U1602222
Organisme : Personnel Training Project of Kunming University of Science and Technology
ID : KKZ3201726045
Informations de copyright
© 2019 Wiley-VHCA AG, Zurich, Switzerland.