Change in capnogram waveform is associated with bronchodilator response and asthma control in children.
asthma
capnography
child
ventilation-perfusion ratio
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
06
11
2018
revised:
02
01
2019
accepted:
20
01
2019
pubmed:
28
2
2019
medline:
4
3
2020
entrez:
28
2
2019
Statut:
ppublish
Résumé
Airway hyper-reactivity, inflammation and remodeling contribute to inhomogeneity of ventilation-perfusion ratio To measure acute changes in the phase 3 slope of the volumetric capnogram after β2-agonist inhalation (ΔSIII), for comparison with airway response based on FEV1 (ΔFEV1), and asthma control. After ethical approval and informed consent, 72 children aged 6-18 y, followed up for asthma underwent spirometry and capnography before and after β-agonist inhalation through a spacer, using a side-stream rapid infrared analyzer. Asthma control was assessed using the GINA questionnaire. Children with positive reversibility tests (defined as ΔFEV1>12%) had a significantly higher ΔSIII (m ± SE: 87.4 ± 41.4) versus those with negative tests (31.3 ± 14.0%, P = 0.001). Uncontrolled asthma was associated with a significantly larger ΔSIII (103.4 ± 64.0%, n = 7) compared to partly controlled (52.0 ± 26.1, n = 24; P = 0.009) and controlled asthma (30.8 ± 16.3, n = 41; P = 0.003). Neither Bohr dead space nor ΔFEV1 were different between asthma control groups. ΔSIII was significantly larger in children with positive response to β2-agonist, and in uncontrolled asthmatics. To our knowledge these are the first data on exhaled CO
Sections du résumé
BACKGROUND
Airway hyper-reactivity, inflammation and remodeling contribute to inhomogeneity of ventilation-perfusion ratio
OBJECTIVES
To measure acute changes in the phase 3 slope of the volumetric capnogram after β2-agonist inhalation (ΔSIII), for comparison with airway response based on FEV1 (ΔFEV1), and asthma control.
SUBJECTS AND METHODS
After ethical approval and informed consent, 72 children aged 6-18 y, followed up for asthma underwent spirometry and capnography before and after β-agonist inhalation through a spacer, using a side-stream rapid infrared analyzer. Asthma control was assessed using the GINA questionnaire.
RESULTS
Children with positive reversibility tests (defined as ΔFEV1>12%) had a significantly higher ΔSIII (m ± SE: 87.4 ± 41.4) versus those with negative tests (31.3 ± 14.0%, P = 0.001). Uncontrolled asthma was associated with a significantly larger ΔSIII (103.4 ± 64.0%, n = 7) compared to partly controlled (52.0 ± 26.1, n = 24; P = 0.009) and controlled asthma (30.8 ± 16.3, n = 41; P = 0.003). Neither Bohr dead space nor ΔFEV1 were different between asthma control groups.
CONCLUSIONS
ΔSIII was significantly larger in children with positive response to β2-agonist, and in uncontrolled asthmatics. To our knowledge these are the first data on exhaled CO
Substances chimiques
Adrenergic beta-Agonists
0
Bronchodilator Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
698-705Informations de copyright
© 2019 Wiley Periodicals, Inc.