Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer.
Animals
Carcinoma, Hepatocellular
/ genetics
Cell Cycle
Cell Line, Tumor
DNA (Cytosine-5-)-Methyltransferases
/ metabolism
Disease Progression
Forkhead Box Protein M1
/ metabolism
Gene Expression Regulation, Neoplastic
Hep G2 Cells
Hepatocyte Nuclear Factor 3-beta
/ metabolism
Humans
Liver Neoplasms
/ genetics
Mice
Mice, Transgenic
Neoplasm Grading
Neoplasms, Experimental
Proto-Oncogene Proteins p21(ras)
/ genetics
Retinoblastoma Protein
/ metabolism
DNA Methyltransferase 3B
Journal
Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
11
09
2018
revised:
10
12
2018
accepted:
22
02
2019
pubmed:
1
3
2019
medline:
29
4
2020
entrez:
1
3
2019
Statut:
ppublish
Résumé
The forkhead box transcription factor FoxM1 is essential for hepatocellular carcinoma (HCC) development, and its overexpression coincides with poor prognosis. Here, we show that the mechanisms by which FoxM1 drives HCC progression involve overcoming the inhibitory effects of the liver differentiation gene FoxA2. First, the expression patterns of FoxM1 and FoxA2 in human HCC are opposite. We show that FoxM1 represses expression of FoxA2 in G
Identifiants
pubmed: 30814128
pii: 1541-7786.MCR-18-0968
doi: 10.1158/1541-7786.MCR-18-0968
pmc: PMC6497570
mid: NIHMS1522826
doi:
Substances chimiques
FOXA2 protein, human
0
FOXM1 protein, human
0
Forkhead Box Protein M1
0
Retinoblastoma Protein
0
Hepatocyte Nuclear Factor 3-beta
135845-92-0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
HRAS protein, human
EC 3.6.5.2
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1063-1074Subventions
Organisme : BLRD VA
ID : I01 BX000131
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA175380
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177655
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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