Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis.
Aging
/ physiology
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ therapeutic use
Cecum
/ surgery
Cells, Cultured
Chitin
/ chemistry
Cytokines
/ metabolism
Disease Models, Animal
Gram-Negative Bacterial Infections
/ complications
Humans
Inflammation Mediators
/ metabolism
Intraabdominal Infections
/ complications
Leukocytes, Mononuclear
/ drug effects
Mice
Mice, Inbred C57BL
Oligosaccharides
/ chemistry
Sepsis
/ etiology
Toll-Like Receptor 4
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 02 2019
27 02 2019
Historique:
received:
17
09
2018
accepted:
31
12
2018
entrez:
1
3
2019
pubmed:
1
3
2019
medline:
24
10
2020
Statut:
epublish
Résumé
In Gram-negative bacterial sepsis, production of excess pro-inflammatory cytokines results in hyperinflammation and tissue injury. Anti-inflammatory cytokines such as IL-10 inhibit inflammation and enhance tissue healing. Here, we report a novel approach to treat septicemia associated with intra-abdominal infection in a murine model by delicately balancing pro- and anti-inflammatory cytokines. A novel oligosaccharide compound AVR-25 selectively binds to the TLR4 protein (IC
Identifiants
pubmed: 30814582
doi: 10.1038/s41598-019-38731-3
pii: 10.1038/s41598-019-38731-3
pmc: PMC6393422
doi:
Substances chimiques
AVR-25
0
Anti-Inflammatory Agents, Non-Steroidal
0
Cytokines
0
Inflammation Mediators
0
Oligosaccharides
0
Toll-Like Receptor 4
0
Chitin
1398-61-4
chitohexaose
6734-92-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2904Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R43AI129164-01
Pays : International
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