A Reappraisal of Sedimentation Nonideality Coefficients for the Analysis of Weak Interactions of Therapeutic Proteins.

Antibodies, Monoclonal / chemistry Chemistry, Pharmaceutical Hydrodynamics Models, Chemical Protein Stability Ultracentrifugation
hydrodynamics protein-protein interactions protein-solvent interactions sedimentation velocity virial coefficients

Journal

The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209

Informations de publication

Date de publication:
27 02 2019
Historique:
received: 11 01 2019
accepted: 11 02 2019
entrez: 1 3 2019
pubmed: 1 3 2019
medline: 3 3 2020
Statut: epublish

Résumé

The study of weak or colloidal interactions of therapeutic proteins in different formulations allows prediction and optimization of protein stability. Various biophysical techniques have been applied to determine the second osmotic virial coefficient B

Identifiants

DOI: 10.1208/s12248-019-0307-0 PMID: 30815745 PMC: PMC6394620
pubmed: 30815745
doi: 10.1208/s12248-019-0307-0
pii: 10.1208/s12248-019-0307-0
pmc: PMC6394620
doi:

Substances chimiques

Antibodies, Monoclonal 0

Types de publication

Journal Article Research Support, N.I.H., Intramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

35

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Auteurs

Sumit K Chaturvedi (SK)

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Drive, Bldg. 13, Rm 3N17, Bethesda, Maryland, 20892, USA.

Peter Schuck (P)

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 13 South Drive, Bldg. 13, Rm 3N17, Bethesda, Maryland, 20892, USA. Peter.Schuck@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › A Reappraisal of Sedimentation Nonideality...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie pharmaceutique › A Reappraisal of Sedimentation Nonideality...
questionsmedicales.fr › Phénomènes physiques › Hydrodynamique › A Reappraisal of Sedimentation Nonideality...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles chimiques › A Reappraisal of Sedimentation Nonideality...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › A Reappraisal of Sedimentation Nonideality...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Ultracentrifugation › A Reappraisal of Sedimentation Nonideality...