Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity.
Animals
Bone Marrow Cells
/ cytology
CD11b Antigen
/ metabolism
Cell Count
Cytokines
/ metabolism
Granulocyte Colony-Stimulating Factor
/ metabolism
Hematopoiesis
Homeostasis
Inflammation Mediators
/ metabolism
Interleukin-17
/ metabolism
Macrophages
/ metabolism
Mast Cells
/ metabolism
Mice, Inbred C57BL
Myeloid Cells
/ metabolism
Neutrophils
/ metabolism
Phenotype
Proto-Oncogene Proteins c-kit
/ metabolism
Signal Transduction
Kit (W-sh) mice
macrophages
mast cell
neutrophils
phagocytosis
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
10
2018
revised:
13
01
2019
accepted:
29
01
2019
pubmed:
1
3
2019
medline:
6
5
2020
entrez:
1
3
2019
Statut:
ppublish
Résumé
The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting the Kit gene display a profound MC deficiency in all tissues and have been extensively used to investigate the role of MC in both physiologic and pathologic conditions. However, these mice present a variety of abnormalities in other immune cell populations that can affect the interpretation of MC-related responses. C57BL/6 Kit
Identifiants
pubmed: 30817046
doi: 10.1002/JLB.4HI1018-390R
doi:
Substances chimiques
CD11b Antigen
0
Cytokines
0
Inflammation Mediators
0
Interleukin-17
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Proto-Oncogene Proteins c-kit
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
633-644Informations de copyright
©2019 Society for Leukocyte Biology.