Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity.
Aged
Aged, 80 and over
Alzheimer Disease
/ metabolism
Animals
Cell Death
/ drug effects
Cerebral Cortex
/ pathology
Cognition Disorders
/ psychology
D-Aspartate Oxidase
/ genetics
D-Aspartic Acid
/ pharmacology
Female
Humans
MAP Kinase Kinase 4
/ metabolism
Mice
Mice, Knockout
Middle Aged
Neuronal Plasticity
/ drug effects
Neurons
/ drug effects
Phosphorylation
/ drug effects
Pregnancy
Primary Cell Culture
Receptors, N-Methyl-D-Aspartate
/ drug effects
Sumoylation
/ drug effects
tau Proteins
/ metabolism
Aging
Alzheimer's disease
JNK
Mouse models
NMDA receptor
SUMOylation
Tau
d-aspartate
d-aspartate oxidase
β-Amiloyd
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
30
12
2018
revised:
19
02
2019
accepted:
24
02
2019
pubmed:
2
3
2019
medline:
27
2
2020
entrez:
2
3
2019
Statut:
ppublish
Résumé
In mammals, free d-aspartate (D-Asp) is abundant in the embryonic brain, while levels remain very low during adulthood as a result of the postnatal expression and activity of the catabolizing enzyme d-aspartate oxidase (DDO). Previous studies have shown that long-lasting exposure to nonphysiological, higher D-Asp concentrations in Ddo knockout (Ddo
Identifiants
pubmed: 30822420
pii: S0014-4886(19)30027-5
doi: 10.1016/j.expneurol.2019.02.014
pii:
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
tau Proteins
0
D-Aspartic Acid
4SR0Q8YD1X
D-Aspartate Oxidase
EC 1.4.3.1
MAP Kinase Kinase 4
EC 2.7.12.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-65Informations de copyright
Copyright © 2019. Published by Elsevier Inc.