[Meningeal melanoma arising from a preexisting meningeal melanocytoma: A clinical, pathological and cytogenetic study about one case].
Transformation d’un mélanocytome méningé en mélanome : étude clinique, histopathologique et cytogénétique.
Biomarkers, Tumor
/ analysis
Cell Transformation, Neoplastic
/ genetics
Comparative Genomic Hybridization
Fatal Outcome
Follow-Up Studies
Humans
Male
Melanocytes
/ pathology
Melanoma
/ complications
Melanoma-Specific Antigens
/ analysis
Meningeal Neoplasms
/ complications
Middle Aged
Neoplasm Proteins
/ analysis
Reoperation
Somatosensory Disorders
/ etiology
Tomography, X-Ray Computed
Vision Disorders
/ etiology
gp100 Melanoma Antigen
Cytogenetics
Cytogénétique
Meningeal melanocytoma
Meningeal melanoma
Mélanocytome méningé
Mélanome méningé
Journal
Annales de pathologie
ISSN: 0242-6498
Titre abrégé: Ann Pathol
Pays: France
ID NLM: 8106337
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
04
12
2018
revised:
23
01
2019
accepted:
25
01
2019
pubmed:
3
3
2019
medline:
17
3
2020
entrez:
3
3
2019
Statut:
ppublish
Résumé
Meningeal melanocytic tumors are rare. We report an exceptional case of transformation of a meningeal melanocytoma in a malignant melanoma. The course of the disease extents from 61-years to 85-years and ends with the death of the patient. Besides histopathological and immunohistochemical data, we also report the array CGH study of the melanocytoma and melanoma components suggesting the malignant transformation from whole chromosome gains in the melanocytoma to additional segmental aberrations in the malignant melanoma. Beyond the rarity of this tumor subtype, this case report highlights the potential interest of molecular analyses for diagnostic and prognostic purposes in the field of meningeal melanocytic tumors.
Identifiants
pubmed: 30824318
pii: S0242-6498(19)30026-4
doi: 10.1016/j.annpat.2019.01.010
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Melanoma-Specific Antigens
0
Neoplasm Proteins
0
PMEL protein, human
0
gp100 Melanoma Antigen
0
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
352-356Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.