Novel bioactive root canal sealer with antibiofilm and remineralization properties.

Anti-Bacterial Agents Biofilms Dental Pulp Cavity Methacrylates Nanoparticles Root Canal Filling Materials
Antibacterial Calcium phosphate nanoparticles Endodontic biofilms Microleakage Root canal sealer Sealing ability

Journal

Journal of dentistry
ISSN: 1879-176X
Titre abrégé: J Dent
Pays: England
ID NLM: 0354422

Informations de publication

Date de publication:
04 2019
Historique:
received: 26 09 2018
revised: 09 02 2019
accepted: 20 02 2019
pubmed: 3 3 2019
medline: 11 1 2020
entrez: 3 3 2019
Statut: ppublish

Résumé

(1) To develop a novel bioactive root canal sealer with antibiofilm and remineralization properties using dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); (2) investigate the effects on E. faecalis biofilm inhibition, sealer flow and sealing ability, compared with an epoxy-resin-based sealer AH Plus; and (3) investigate the calcium (Ca) and phosphate (P) ion release from the sealers. A series of dual-cure endodontic sealers were formulated with DMAHDM and NACP at 5% and 20% by mass, respectively. Flow properties and sealing ability of the sealers were measured. Colony-forming units (CFU), live/dead assay, and polysaccharide production of biofilms on sealers were determined. Ca and P ion releases from the sealers were measured. The new sealer containing 20% NACP and 5% DMAHDM yielded a paste flow of (28.99 ± 0.69) mm, within the range of ISO recommendations. The sealing properties of the sealer with 5% DMAHDM and 20% NACP were similar to a commercial control (p > 0.05). The sealer with DMAHDM decreased E. faecalis biofilm CFU by more than 4 orders of magnitude, compared to AH plus and experimental controls. The sealer with 20% NACP and 5% DMAHDM had relatively high levels of Ca and P ion release necessary for remineralization. A new bioactive endodontic sealer was developed with strong antibiofilm activity against E. faecalis biofilms and high levels of Ca and P ion release for remineralization, without compromising the paste flow and sealing properties. The bioactive antibacterial and remineralizing root canal sealer is promising to inhibit E. faecalis biofilms to prevent endodontic treatment failure and secondary endodontic infections, while releasing high levels of Ca and P ions that could remineralize and strengthen the tooth structures and potentially prevent future root fractures and teeth extractions.

Identifiants

DOI: 10.1016/j.jdent.2019.02.006 PMID: 30825569
pubmed: 30825569
pii: S0300-5712(18)30517-7
doi: 10.1016/j.jdent.2019.02.006
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Methacrylates 0
Root Canal Filling Materials 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-76

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Bashayer H Baras (BH)

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.

Suping Wang (S)

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Operative Dentistry and Endodontics & Stomatology Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Mary Anne S Melo (MAS)

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.

Franklin Tay (F)

Department of Endodontics, Dental College of Georgia, Augusta University, Augusta, GA, USA.

Ashraf F Fouad (AF)

Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7450, USA.

Dwayne D Arola (DD)

Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA.

Michael D Weir (MD)

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA. Electronic address: mweir@umaryland.edu.

Hockin H K Xu (HHK)

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: hxu@umaryland.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Novel bioactive root canal sealer with...
questionsmedicales.fr › Phénomènes microbiologiques › Biofilms › Novel bioactive root canal sealer with...
questionsmedicales.fr › Système stomatognathique › Bouche › Denture › Composants dentaires › Cavité pulpaire de la dent › Novel bioactive root canal sealer with...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acrylates › Méthacrylates › Novel bioactive root canal sealer with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Novel bioactive root canal sealer with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux dentaires › Produits d'obturation des canaux radiculaires › Novel bioactive root canal sealer with...