Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells.
Animals
Cells, Cultured
Cytokines
/ metabolism
Fingolimod Hydrochloride
/ metabolism
Humans
Immunity, Innate
Lymphocytes
/ drug effects
Mice
Mice, Inbred C57BL
Mice, Transgenic
Multiple Sclerosis
/ immunology
Sphingosine-1-Phosphate Receptors
/ agonists
Th1 Cells
/ immunology
Th17 Cells
/ immunology
Tissue Distribution
FTY720
Fingolimod
ILC1
ILC3
S1PR1
SEW2871
multiple sclerosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
10
2018
accepted:
25
01
2019
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
28
10
2020
Statut:
epublish
Résumé
Sphingosine-1 phosphate receptor 1 (S1PR1) is expressed by lymphocytes and regulates their egress from secondary lymphoid organs. Innate lymphoid cell (ILC) family has been expanded with the discovery of group 1, 2 and 3 ILCs, namely ILC1, ILC2 and ILC3. ILC3 and ILC1 have remarkable similarity to CD4+ helper T cell lineage members Th17 and Th1, respectively, which are important in the pathology of multiple sclerosis (MS). Whether human ILC subsets express S1PR1 or respond to its ligands have not been studied. In this study, we used peripheral blood/cord blood and tonsil lymphocytes as a source of human ILCs. We show that human ILCs express S1PR1 mRNA and protein and migrate toward S1P receptor ligands. Comparison of peripheral blood ILC numbers between fingolimod-receiving and treatment-free MS patients revealed that,
Identifiants
pubmed: 30828332
doi: 10.3389/fimmu.2019.00217
pmc: PMC6385997
doi:
Substances chimiques
Cytokines
0
S1PR1 protein, human
0
Sphingosine-1-Phosphate Receptors
0
Fingolimod Hydrochloride
G926EC510T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
217Références
Science. 2002 Apr 12;296(5566):346-9
pubmed: 11923495
J Immunol. 2003 Oct 1;171(7):3500-7
pubmed: 14500646
J Biol Chem. 2004 Apr 9;279(15):15396-401
pubmed: 14732704
Nature. 2004 Jan 22;427(6972):355-60
pubmed: 14737169
Nat Immunol. 2004 Jul;5(7):713-20
pubmed: 15184895
Am J Transplant. 2005 Mar;5(3):529-36
pubmed: 15707407
Science. 2005 Sep 9;309(5741):1735-9
pubmed: 16151014
Science. 2006 Aug 25;313(5790):1126-30
pubmed: 16931762
Science. 2007 Apr 13;316(5822):295-8
pubmed: 17363629
Nat Immunol. 2007 Dec;8(12):1337-44
pubmed: 17965716
Nat Immunol. 2008 Jan;9(1):42-53
pubmed: 18037890
Immunity. 2008 Dec 19;29(6):958-70
pubmed: 19084435
N Engl J Med. 2010 Feb 4;362(5):402-15
pubmed: 20089954
Nature. 2010 Apr 29;464(7293):1371-5
pubmed: 20393462
Immunity. 2010 Nov 24;33(5):736-51
pubmed: 21093318
Trends Pharmacol Sci. 2011 Jan;32(1):16-24
pubmed: 21159389
Immunity. 2011 Jan 28;34(1):122-34
pubmed: 21194981
Nat Immunol. 2011 Apr;12(4):320-6
pubmed: 21336274
Nat Immunol. 2011 May;12(5):383-90
pubmed: 21502992
J Exp Med. 2011 Jun 6;208(6):1127-33
pubmed: 21576383
Mucosal Immunol. 2012 Jan;5(1):99-109
pubmed: 22089030
Annu Rev Immunol. 2012;30:69-94
pubmed: 22149932
Science. 2012 Jun 8;336(6086):1321-5
pubmed: 22674331
Neurology. 2012 Nov 6;79(19):1942-3
pubmed: 23035058
Neurology. 2012 Nov 6;79(19):2004-5
pubmed: 23035063
Neurology. 2012 Nov 6;79(19):2000-3
pubmed: 23035065
Neurology. 2012 Nov 6;79(19):2006-7
pubmed: 23035074
Mult Scler. 2012 Nov;18(11):1650-2
pubmed: 23100527
Nature. 2013 Feb 14;494(7436):261-5
pubmed: 23334414
Annu Rev Biochem. 2013;82:637-62
pubmed: 23527695
Mucosal Immunol. 2014 Jan;7(1):143-54
pubmed: 23715173
Immunity. 2013 Aug 22;39(2):386-99
pubmed: 23954130
Blood. 2014 Jul 31;124(5):700-9
pubmed: 24778151
Nat Commun. 2014 Aug 05;5:4603
pubmed: 25091235
Immunity. 2014 Sep 18;41(3):354-365
pubmed: 25238093
Immunity. 2014 Sep 18;41(3):366-374
pubmed: 25238094
Immunity. 2014 Dec 18;41(6):988-1000
pubmed: 25500367
Nat Immunol. 2015 Jan;16(1):1-5
pubmed: 25521670
Science. 2015 May 29;348(6238):1031-5
pubmed: 25908663
Science. 2015 May 22;348(6237):aaa6566
pubmed: 25999512
Eur J Immunol. 2015 Aug;45(8):2171-82
pubmed: 26031799
Immunity. 2015 Jul 21;43(1):146-60
pubmed: 26187413
Immunity. 2015 Jul 21;43(1):187-99
pubmed: 26200014
Cell. 2015 Oct 8;163(2):381-93
pubmed: 26411290
Science. 2015 Nov 20;350(6263):981-5
pubmed: 26472762
Eur J Immunol. 2016 Apr;46(4):941-51
pubmed: 26683421
Immunol Lett. 2016 Nov;179:2-8
pubmed: 26844414
Nat Immunol. 2016 Jun 21;17(7):765-74
pubmed: 27328006
J Allergy Clin Immunol. 2016 Nov;138(5):1265-1276
pubmed: 27677386
Immunology. 2017 Mar;150(3):265-275
pubmed: 27935637
Nat Rev Rheumatol. 2017 Mar;13(3):164-173
pubmed: 28148916
Cell. 2017 Mar 9;168(6):1086-1100.e10
pubmed: 28283063
J Allergy Clin Immunol. 2018 Jun;141(6):2265-2268.e1
pubmed: 29248494
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Science. 2018 Jan 5;359(6371):114-119
pubmed: 29302015